Objective: To summarize the distribution characteristics and changes of pathogens of community-acquired pneumonia in children from our hospital

so as to guide the rational application of antibiotics. Methods: Clinical data of 2

786 children with pneumonia in our hospital in 2013

2015 and 2017 were statistically analyzed. Sputum culture and drug sensitivity test were performed. The distribution characteristics of pathogens and changes of drug resistance were compared at 3 years. Results: The majority of patients with pneumonia were infants

accounting for 59.9%. And the proportion was 61.5% in winter and spring. A total of 630 cases (22.6%) were diagnosed with pathogens

of which G- accounted for 67.9%. The top three pathogens were respectively Staphylococcus aureus (28.1%)

Escherichia coli (19.2%) and Klebsiella pneumoniae (16.1%). The detection rate of S. aureus

Pseudomonas aeruginosa

Acinetobacter baumannii and Haemophilus influenzae increased year by year. Drug resistance rates of S. aureus to amoxicillin/potassium clavulanate were <15%

drug resistance rates of K. pneumoniae and Escherichia coli to amoxicillin/potassium clavulanate and piperacillin/tazobactam were <20%

and drug resistance rates of K. pneumoniae and E. coli to cephalosporin were higher but in a decreasing trend year by year. The resistance rate of major G- to most antibiotics decreased year by year (P<0.05). Conclusion: The majority of children with community-acquired pneumonia are infants and young children

and the pathogens are mostly G-. Drug resistance rates of main pathogens G- are decreasing year by year. Antibiotics containing β-lactamase inhibitors can be used as the first options.