Objective: To research the stability of pediatric parenteral nutrition solution

to explore the influencing factors of stability

so as to provide reliable basis for improving the safety of clinical application. Methods: Pediatric parenteral nutrient solution was randomly selected and its appearance was observed by naked eyes. Dynamic light scattering method was used to determine the mean droplet size (MDS) of lipid emulsion

and light blocking method was used to determine the percentage of fat residing in globules >5μ m (PFAT5) and distribution of particle size. Multiple regression analysis was used to explore the influencing factors of stability of parenteral nutrition. Results: (1) The MDS of long chain lipid emulsion group (n=13) was 274.870 (270.495

281.665) nm

PFAT5 was 0.003

40 (0.002

04

0.005

88); the MDS of multi-oil lipid emulsion group (n=6) was 308.348 (307.105

314.250) nm

PFAT5 was 0.003

91 (0.001

82

0.005

38); the difference in MDS of lipid emulsion between two groups was statistically significant (P<0.01)

while the difference in PFAT5 was not statistically significant (P>0.05). (2) Influencing factor of stability (n=19): Multiple regression analysis suggested that there was linear relationship between amino acid concentration and PFAT5 value (P<0.01). No linear relationship was found between the lipid emulsion concentration

glucose concentration and monovalent

divalent cation electrolyte concentration and PFAT5 (P>0.05). (3) The particle size distribution of parenteral nutrition mainly confined from 1.8 to 5.0 μm

with a large-diameter droplet tail >5.0 μm. Conclusion: Parenteral nutrition with long chain lipid emulsion is more stable than that with multi-oil lipid emulsion

and amino acids provide a certain degree of protection to the stability. Based on the droplet size and the particle size distribution in all-in-one nutrition solution

1.2 μm filter is recommended to improve the safety and specification of parenteral nutrition.