Different Doses of Ibuprofen in the Treatment of Very Low Birth Weight Infants with Patent Ductus Arteriosus

Wang Wanli; Yang Guanshan

doi:10.13407/j.cnki.jpp.1672-108X.2020.05.009

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Different Doses of Ibuprofen in the Treatment of Very Low Birth Weight Infants with Patent Ductus Arteriosus

更新时间：2022-11-03

- Different Doses of Ibuprofen in the Treatment of Very Low Birth Weight Infants with Patent Ductus Arteriosus
- Vol. 26, Issue 5, Pages: 29-32(2020)
- 作者机构：
  
  陕西省安康市中医医院,陕西,安康,725200
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2020.05.009
  CLC：
- Published：2020，
  
  Published Online：10 May 2020，
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Wang Wanli, Yang Guanshan. Different Doses of Ibuprofen in the Treatment of Very Low Birth Weight Infants with Patent Ductus Arteriosus. [J]. 26(5):29-32(2020)
DOI：

Wang Wanli, Yang Guanshan. Different Doses of Ibuprofen in the Treatment of Very Low Birth Weight Infants with Patent Ductus Arteriosus. [J]. 26(5):29-32(2020) DOI： 10.13407/j.cnki.jpp.1672-108X.2020.05.009.

摘要

目的：探究不同剂量布洛芬治疗动脉导管未闭（PDA）极低出生体质量儿的效果及安全性，为布洛芬治疗PDA极低出生体质量儿提供参考。方法：选取2017年2月30日至2019年4月30日我院收治的180例胎龄<37周且体质量<1 500 g的PDA患儿，根据随机数字表法分为高剂量组90例和低剂量组90例。高剂量组患儿接受第1天20 mg/kg、第2天10 mg/kg、第3天10 mg/kg布洛芬治疗，低剂量组患儿接受第1天10 mg/kg、第2天5 mg/kg、第3天5 mg/kg布洛芬治疗，第一疗程失败患儿接受第二疗程治疗，治疗方法同第一疗程。观察两组患儿治疗后PDA关闭率、治疗期间不良反应发生率、病死率、治疗前后肺动脉端内径变化情况。结果：两组患儿治疗期间病死率及不良反应发生率比较差异均无统计学意义（P>0.05）。治疗第一疗程结束后高剂量组PDA治疗成功率高于低剂量组，PDA治疗失败率低于低剂量组（P<0.05）。第二疗程两组患儿PDA治疗成功率比较差异无统计学意义（P>0.05）。两组患儿两个疗程累计PDA治疗成功率比较差异有统计学意义（P<0.05）。治疗两个疗程后两组患儿动脉导管重新开放率比较差异无统计意义（P>0.05）。治疗前，两组患儿肺动脉端内径比较差异无统计学意义（P>0.05），治疗后两组肺动脉端内径均低于治疗前（P<0.05），治疗第一、二个疗程后，高剂量组肺动脉端内径均低于低剂量组，差异有统计学意义（P<0.05）。结论：高剂量布洛芬治疗PDA极低出生体质量儿的效果优于低剂量，且安全性高。

Abstract

Objective: To investigate the efficacy and safety of different doses of ibuprofen in the treatment of very low birth weight infants with patent ductus arteriosus (PDA)

so as to provide reference for the treatment. Methods: A total of 180 children with PDA who were less than 37 weeks and less than 1

500 g in body mass in our hospital from Feb. 30

2017 to Apr. 30

2019 were enrolled. All patients were divided into the high-dose group and the low-dose group via the random number table

with 90 cases in each group. Children in the high-dose group received ibuprofen of 20 mg/kg on the 1st day

10 mg/kg on the 2nd day

and 10 mg/kg on the 3rd day. Children in the low-dose group received ibuprofen of 10 mg/kg on the 1st day

5 mg/kg on the 2nd day

and 5 mg/kg the 3rd day. If the first course of treatment failed

the second course of treatment was given

the second course of treatment was the same as the first. The PDA closure rate after treatment

the incidence of adverse drug reactions and mortality during treatment

and the diameter of pulmonary artery before and after treatment of two groups were observed. Results: There was no statistically significant difference in mortality and incidence of adverse drug reactions between two groups during treatment (P>0.05). After the first course of treatment

the success rate of PDA treatment in the high-dose group was higher than that in the low-dose group

and the failure rate of PDA treatment was lower than that in the low-dose group (P<0.05). There was no significant difference in the success rate of PDA treatment between two groups in the second course of treatment (P>0.05). There was statistically significant difference in the cumulative success rate of PDA treatment between two groups after two courses of treatment (P<0.05). After two courses of treatment

there was no statistically significant difference in the reopening rate of arterial catheter between two groups (P>0.05). Before treatment

there was no statistically significant difference in the inner diameter of pulmonary artery between two groups (P>0.05). After treatment

the inner diameter of pulmonary artery in two groups was lower than that before treatment (P<0.05). After two courses of treatment

the inner diameter of pulmonary artery in the high-dose group was lower than that in the low-dose group

and the difference was statistically significant (P<0.05). Conclusion: The efficacy of high-dose ibuprofen in the treatment of very low birth weight infants with PDA is better than that of low-dose ibuprofen

with higher safety.

关键词

剂量布洛芬极低出生体质量儿动脉导管未闭

Keywords

osebuprofenery low birth weight infantspatent ductus arteriosus

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