Significance of Changes of Platelet in Children with Kawasaki Disease during Different Period in Clinical Therapy Strategies

Chen Xiaodong; Zhang Jing

doi:10.13407/j.cnki.jpp.1672-108X.2020.05.006

您当前的位置：

首页 >

文章列表页 >

Significance of Changes of Platelet in Children with Kawasaki Disease during Different Period in Clinical Therapy Strategies

更新时间：2022-11-03

- Significance of Changes of Platelet in Children with Kawasaki Disease during Different Period in Clinical Therapy Strategies
- Vol. 26, Issue 5, Pages: 20-23(2020)
- 作者机构：
  
  重庆医科大学附属儿童医院，国家住院医师规范化培训示范基地，儿童发育疾病研究教育部重点实验室，儿童发育重大疾病国家国际科技合作基地，儿科学重庆市重点实验室,重庆,400014
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2020.05.006
  CLC：
- Published：2020，
  
  Published Online：10 May 2020，
扫描看全文
Chen Xiaodong, Zhang Jing. Significance of Changes of Platelet in Children with Kawasaki Disease during Different Period in Clinical Therapy Strategies. [J]. 26(5):20-23(2020)
DOI：

Chen Xiaodong, Zhang Jing. Significance of Changes of Platelet in Children with Kawasaki Disease during Different Period in Clinical Therapy Strategies. [J]. 26(5):20-23(2020) DOI： 10.13407/j.cnki.jpp.1672-108X.2020.05.006.

摘要

目的：探讨血小板在川崎病（KD）患儿急性期及恢复期变化的临床意义。方法：回顾性收集我院2016年的KD住院患儿临床资料，探讨急性期血小板变化与静脉丙种球蛋白（IVIG）治疗无反应KD及冠状动脉病变（CAL）之间的关系，以及在恢复期对小剂量阿司匹林应用的指导意义。结果：本研究共纳入808例KD患儿。IVIG治疗无反应组36例（4.46%），IVIG治疗有反应组772例（95.54%）。IVIG治疗无反应组患儿的血小板计数（PLT）、血小板压积（PCT）低于IVIG治疗有反应组，血小板平均体积（MPV）高于IVIG治疗有反应组（P均<0.05）。恢复期有CAL（CAL组）178例（22.03%），恢复期无CAL（nCAL组）630例（77.97%）。规律随访并服用小剂量阿司匹林的恢复期nCAL患儿420例，服药6周后321例（76.43%）PLT可降至400×109/L以下，服药8周为355例（84.52%），差异有统计学意义（c2=8.76，P<0.05）；12周为371例（88.33%），与8周时比较差异无统计学意义（c2=2.60，P>0.05）。结论：PLT、PCT、MPV急性期变化可能与IVIG治疗无反应相关，与CAL无明显关系。对无CAL或一过性冠脉扩张的绝大多数KD患儿，口服小剂量阿司匹林疗程在6~8周适宜。

Abstract

Objective: To probe into the clinical significance of changes of platelet (PLT) in children with Kawasaki disease (KD) during acute and recovery period. Methods: Clinical data of hospitalized children with KD in our hospital in 2016 were retrospectively collected to investigate the relationship between changes of platelet during acute period and non-responsive intravenous gamma globulin (IVIG) treatment of KD and coronary artery disease (CAL)

the guiding significance on the application of low-dose aspirin during recovery period was analyzed. Results: A total of 808 children with KD were collected. There were 36 cases (4.46%) in non-responsive IVIG group and 772 cases (95.54%) in responsive IVIG group. The PLT count and platelet hematocrit (PCT) of children in non-responsive IVIG group were lower than those in responsive IVIG group

and the mean platelet volume (MPV) was higher than that in responsive IVIG group (P<0.05). There were 178 cases (22.03%) with CAL (CAL group) and 630 cases (77.97%) without CAL (nCAL group) during recovery period. Totally 420 cases in nCAL group took low-dose aspirin regularly were followed up. PLT count in 321 cases (76.43%) was lower than 400×109/L after 6 weeks

355 cases (84.52%) was lower than 400×109/L after 8 weeks

the difference was statistically significant (c2=8.76

P<0.05). PLT count in 371 cases (88.33%) was lower than 400×109/L after 12 weeks

compared with 8 weeks

the difference was not statistically significant (c2=2.60

P>0.05). Conclusion: Changes of PLT

PCT

and MPV during acute period may be related to non-responsive IVIG treatment

and have no significant relationship with CAL. For the majority of children with KD and without CAL or transient coronary dilatation

6 to 8 weeks of oral low-dose aspirin treatment is appropriate.

关键词

川崎病血小板急性期恢复期儿童

Keywords

Kawasaki diseaseplateletacute periorecovery periochildren

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Development and Validation of an Individualized Nomogram to Predict Risk of Kawasaki Disease in Children

Analysis of 36 Cases of Drug Poisoning in Children in a Grade III, Level A General Hospital andConsideration on Pharmaceutical Care

Application of Dexmedetomidine Combined with Hydromorphone Nasal Drip in Sedation of Mother-InfantSeparation before Adenoidectomy

Sirolimus in the Treatment of 5 Cases of Blue Rubber Bleb Nevus Syndrome in Children and Literature Review

Systematic Review on Efficacy and Safety of Zoledronic Acid in the Treatment of Bone Metabolic Disordersin Children

Related Author

Wang Dan

Chen Ai

Wang Peng

Xu Ying

Zhang Xiaoming

Zhang Shaonan

Li Changsong

Li Yunxiang

Related Institution

Affiliated Hospital of Southwest Medical University, Sichuan Luzhou

SichuanProvincial Hospital for Women and Children, Chengdu

The Second People’ s Hospital of Anhui Wuhu, Anhui Wuhu

Jiangsu Taizhou People’s Hospital, Jiangsu Taizhou

Children’s Hospital Affiliated to Zhengzhou University,Henan Children’s Hospital, Zhengzhou Children’s Hospital, Zhengzhou Key Laboratory of Children’s Digestive Diseases

⁰