Meta-Analysis of Cyclophosphamide Combined with Glucocorticoid in the Treatment of Henoch-Schönlein Purpura Nephritis

Lu Yan; Deng Fang; Zhang Luodan

doi:10.13407/j.cnki.jpp.1672-108X.2020.03.002

您当前的位置：

首页 >

文章列表页 >

Meta-Analysis of Cyclophosphamide Combined with Glucocorticoid in the Treatment of Henoch-Schönlein Purpura Nephritis

更新时间：2022-11-03

- Meta-Analysis of Cyclophosphamide Combined with Glucocorticoid in the Treatment of Henoch-Schönlein Purpura Nephritis
- Vol. 26, Issue 3, Pages: 4-8(2020)
- 作者机构：
  
  安徽医科大学第一附属医院,安徽,合肥,230002
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2020.03.002
  CLC：
- Published：2020，
  
  Published Online：10 March 2020，
扫描看全文
Lu Yan, Deng Fang, Zhang Luodan. Meta-Analysis of Cyclophosphamide Combined with Glucocorticoid in the Treatment of Henoch-Schönlein Purpura Nephritis. [J]. 26(3):4-8(2020)
DOI：

Lu Yan, Deng Fang, Zhang Luodan. Meta-Analysis of Cyclophosphamide Combined with Glucocorticoid in the Treatment of Henoch-Schönlein Purpura Nephritis. [J]. 26(3):4-8(2020) DOI： 10.13407/j.cnki.jpp.1672-108X.2020.03.002.

摘要

目的：评价环磷酰胺联合糖皮质激素治疗儿童紫癜性肾炎的疗效及安全性。方法：电子检索PubMed、EMBase、the Cochrane Library、中国生物医学文献数据库（CBM）、中国期刊全文数据库、万方数据库和维普中文科技期刊数据库中有关环磷酰胺治疗儿童紫癜性肾炎的随机对照试验研究，检索时间为建库至2018年10月。由2位研究者按纳入标准与排除标准独立筛选文献，提取资料并按照Cochrane系统评价方法进行文献质量评价，采用RevMan 5.3软件进行Meta分析。结果：共纳入15篇RCT文献683例紫癜性肾炎患儿。Meta分析结果显示，环磷酰胺联合糖皮质激素组与单用激素组相比，在总体缓解率、24小时尿蛋白水平、血清白蛋白水平、血肌酐水平方面具有优势（P均<0.05），且能减少激素副作用（P<0.01），但可增加胃肠道反应、白细胞减少的风险（P均<0.05）。两组在呼吸道感染、血压升高及肝功能异常发生率等方面比较差异无统计学意义（P均>0.05）。结论：基于现有证据，环磷酰胺联合糖皮质激素治疗肾病综合征型紫癜性肾炎安全有效。

Abstract

Objective: To systematically evaluate the efficacy and safety of cyclophosphamide combined with glucocorticoid in the treatment of Henoch-Schönlein purpura nephritis. Methods: PubMed

EMBase

the Cochrane Library

CBM

CNKI

Wanfang database and VIP database were retrieved to collect the randomized controlled trial of cyclophosphamide combined with glucocorticoid in the treatment of Henoch-Schönlein purpura nephritis. The retrieval time was from the establishment of the database to Oct. 2018. Literature were independently screened by two investigators based on inclusion and exclusion criteria. Data were extracted and literature quality was evaluated according to the Cochrane systematic review method. Meta-analysis was performed by using RevMan 5.3 software. Results: Fifteen clinical studies with a total of 638 children were included. The results of the Meta-analysis showed that compared with the hormone group alone

the cyclophosphamide combined glucocorticoid group had advantages in overall remission rate

24 h urine protein level

serum albumin level and blood creatinine level (P<0.05)

and reducing side effects (P<0.01)

but increasing the risk of gastrointestinal reactions and leukopenia (P<0.05). There was no significant difference between two groups in the incidence of respiratory tract infection

elevated blood pressure and liver dysfunction (P>0.05). Conclusion: Based on the available evidence

cyclophosphamide combined with glucocorticoids in the treatment of children with Henoch-Schönlein purpura nephritis is effective and safe.

关键词

环磷酰胺紫癜性肾炎儿童Meta分析

Keywords

cyclophosphamideHenoch-Schönlein purpura nephritischildrenMeta-analysis

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Meta-Analysis of Efficacy and Safety of Milrinoneon Injection in the Treatment of Children with Congenital Heart Disease Complicated with Severe Pneumonia and Heart Failure

Meta-Analysis of Probiotics in the Treatment of Functional Abdominal Pain in Children

Meta-Analysis on Efficacy of Gamma Globulin Combined with Glucocorticoid and Glucocorticoid Alone in the Treatment of Children with Abdominal Henoch-Schönlein Purpura

Meta-Analysis of Yupingfeng Combined with Pidomomod in the Treatment of Children with Recurrent Respiratory Infection

Meta-Analysis of Efficacy of Astragalus Injection Combined with Chemotherapy in the Treatment of Children with Acute Lymphoblastic Leukemia

Related Author

Zhang Xiangyu

Wang Yazhou

Zhang Dufei

Li Huifang

Fu Jinjin

Wang Jun

Duan Yuhang

Zheng Mengqiu

Related Institution

Hainan Women and Children’s Medical Center, Children’s Hospital of Hainan

Japan Friendship School of Clinical Medicine, Beijing University of Chinese Medicine,, China

Department of Pediatrics, China-Japan Friendship Hospital

Kunming City Maternal and Child Health Hospital, Kunming

Yunnan Cancer Hospital, Kunming

⁰