Preliminary Study on Lung Function Damage in Children with Congenital Lung Cystic Lesions

Jiang Maolin; Li Hongbo; Song Jishuo; Wu Chun; Pan Zhengxia; Gong Caihui; Liu Sha; Li Yonggang; Wang Gang; Dai Jiangtao

doi:10.13407/j.cnki.jpp.1672-108X.2020.02.003

您当前的位置：

首页 >

文章列表页 >

Preliminary Study on Lung Function Damage in Children with Congenital Lung Cystic Lesions

更新时间：2022-11-03

- Preliminary Study on Lung Function Damage in Children with Congenital Lung Cystic Lesions
- Vol. 26, Issue 2, Pages: 7-10(2020)
- 作者机构：
  
  重庆医科大学附属儿童医院，儿童发育疾病研究教育部重点实验室，儿童发育重大疾病国家国际合作基地，儿科学重庆市重点实验室,重庆,400014
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2020.02.003
  CLC：
- Published：2020，
  
  Published Online：10 February 2020，
扫描看全文
Jiang Maolin, Li Hongbo, Song Jishuo, et al. Preliminary Study on Lung Function Damage in Children with Congenital Lung Cystic Lesions. [J]. 26(2):7-10(2020)
DOI：

Jiang Maolin, Li Hongbo, Song Jishuo, et al. Preliminary Study on Lung Function Damage in Children with Congenital Lung Cystic Lesions. [J]. 26(2):7-10(2020) DOI： 10.13407/j.cnki.jpp.1672-108X.2020.02.003.

摘要

目的：探讨儿童先天性肺囊性疾病对肺功能的影响，为临床手术治疗提供参考。方法：选取2014年1月至2018年9月重庆医科大学附属儿童医院确诊并拟行手术治疗的先天性肺囊性疾病患儿49例，术前测定患儿肺功能，并进行统计分析。其中<42月龄23例，采用潮气呼吸法测定肺功能；≥42月龄26例，采用常规通气法测定肺功能。结果：支气管源性囊肿（BC）18例（36.8%），其中<42月龄组5例，TPTEF/TE、VPEF/VE、PF/V25、TI/TE存在异常，提示存在小气道中度阻塞及大气道轻度阻塞；≥42月龄组13例，FVC、FEV1、FEF75、MMEF存在异常，提示存在轻度混合型通气功能障碍。先天性肺囊性腺瘤样畸形（CCAM）15例（30.6%），其中<42月龄组8例，TPTEF/TE、PF/V25、TI/TE存在异常，提示大、小气道轻度阻塞；≥42月龄组7例，肺功能正常。肺隔离症（PS）10例（20.4%），其中<42月龄组7例，TEF50/TIF50、TI/TE存在异常，提示大气道轻度阻塞；≥42月龄组3例，肺功能正常。先天性大叶性肺气肿（CLE）6例（12.2%），其中<42月龄组3例，TPTEF/TE、VPEF/VE 、PF/V25、TEF50/TIF50、TI/TE存在异常，提示小气道中度阻塞及大气道轻度阻塞；≥42月龄组3例，肺功能正常。在临床表现上，<42月龄组中有肺部感染史者11例（47.8%），≥42月龄组有肺部感染史者20例（76.9%）。结论：先天性肺囊性疾病对儿童造成了以不同程度大小气道通气功能障碍为主要表现的肺功能损害，小年龄组肺功能受损程度更为明显，年长儿更易出现肺部反复感染，早期手术是优先的治疗选择。

Abstract

Objective: To probe into the effects of congenital lung cystic lesions on children’s lung function

so as to provide reference for clinical surgical treatment. Methods: From Jan. 2014 to Sept. 2018

totally 49 children diagnosed with congenital lung cystic lesions in Children’s Hospital of Chongqing Medical University were extracted

preoperative lung function was measured and statistically analyzed. Among them

23 children were <42 months

and the lung function was measured by tidal breathing method; 26 children were ≥42 months

and the lung function was measured by conventional ventilation method. Results: There were 18 cases (36.8%) of bronchogenic cysts (BC)

among which 5 cases (<42 months) had abnormalities in TPTEF/TE

VPEF/VE

PF/V25 and TI/TE

indicating moderate obstruction of small airway and mild obstruction of large airway; and 7 cases (≥42 months) had abnormalities in FVC

FEV1

FEF75 and MMEF

suggesting mild mixed ventilation dysfunction. There were 15 cases (30.6)% of congenital cystic adenomatoid malformation (CCAM)

among which 8 cases (<42 months) had abnormalities in TPTEF/TE

PF/V25 and TI/TE

suggesting mild obstruction of large and small airway; 7 cases (≥42 months) had normal lung function. There were 10 cases (20.4%) of pulmonary sequestration (PS)

among which 7 cases (<42 months) had abnormalities in TEF50/TIF50 and TI/TE

suggesting mild obstruction of large airway; 3 cases (≥42 months) had normal lung function. There were 6 cases (12.2%) of congenital lobar emphysema (CLE)

among which 3 cases (<42 months) had abnormalities in TPTEF/TE

VPEF/VE

PF/V25

TEF50/TIF50 and TI/TE

suggesting moderate obstruction of small airway and mild obstruction of large airway; 3 cases (≥42 months) had normal lung function. In terms of clinical manifestations

11 cases (47.8%) in the <42-month group had the history of lung infection

and 20 cases (76.9%) in the ≥42-month group had the history of lung infection. Conclusion: Congenital lung cystic lesions causes lung function impairment in children

mainly manifested by airway dysfunction at different degree. The degree of impairment of lung function is more obvious in younger age groups

and older age groups are more prone to have repeated lung infections. Early surgery is the preferred treatment option.

关键词

儿童先天性肺囊性疾病肺功能

Keywords

childrencongenital lung cystic lesionslung function

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Analysis of 36 Cases of Drug Poisoning in Children in a Grade III, Level A General Hospital andConsideration on Pharmaceutical Care

Application of Dexmedetomidine Combined with Hydromorphone Nasal Drip in Sedation of Mother-InfantSeparation before Adenoidectomy

Sirolimus in the Treatment of 5 Cases of Blue Rubber Bleb Nevus Syndrome in Children and Literature Review

Systematic Review on Efficacy and Safety of Zoledronic Acid in the Treatment of Bone Metabolic Disordersin Children

Drug Utilization Evaluation of Voriconazole for Injection in Children Based on Weighted Technique for Order Preference by Similarity to Ideal Solution Method

Related Author

Wang Peng

Xu Ying

Zhang Xiaoming

Zhang Shaonan

Li Changsong

Li Yunxiang

Li Xiaojing

Sun Canlin

Related Institution

The Second People’ s Hospital of Anhui Wuhu, Anhui Wuhu

Jiangsu Taizhou People’s Hospital, Jiangsu Taizhou

Children’s Hospital Affiliated to Zhengzhou University,Henan Children’s Hospital, Zhengzhou Children’s Hospital, Zhengzhou Key Laboratory of Children’s Digestive Diseases

Kunming Children’s Hospital / Children’s Hospital of Kunming Medical University, Kunming

Kunming MedicalUniversity, Kunming

⁰