Objective: To investigate the distribution characteristics and drug-resistance of pathogens isolated from sputum culture of children with infectious pneumonia in this region

so as to provide reference for clinical treatment. Methods: Data of children with pneumonia hospitalized in pediatrics of our hospital from Mar. 2017 to Feb. 2018 were collected for retrospective analysis. Results: Of the 517 children

213 cases of bacterial culture were positive in children’s sputum

with positive rate of 41.20%. Totally 239 strains of pathogens were isolated

respectively Streptococcus pneumoniae (34.73%)

Haemophilus influenzae (33.05℅)

Moraxella catarrhal (19.25%) and Staphylococcus aureus (6.69%). S. pneumoniae was highly resistant to erythromycin and clindamycin (>95%) and highly sensitive to penicillin

vancomycin and linezolid. The resistance rate of S. aureus to ampicillin and penicillin reached 100%

and the resistance rate to erythromycin and clindamycin reached 93.7%

and S. aureus were sensitive to linezoild

vancomycin and teicoplanin. H. influenzae and M. catarrhal were highly resistant to azithromycin. H. influenzae had high resistance to ampicillin

cefaclor and cefuroxime (>60%)

and low resistance to cefotaxime

amoxicillin/clavulanic acid. The resistance rate of M. catarrhal to erythromycin was 78.57%

and M. catarrhal was highly sensitive to amoxicillin/clavulanic acid. Conclusion: S. pneumoniae and H. influenzae are the main pathogens of pneumonia in children in this region

and the detection rate varies in different seasons. Antibiotics should be reasonably selected according to the type of pathogens and drug sensitivity during treatment

so as to reduce the generation of drug-resistance strains.