Retrospective Analysis of Serum Concentration Monitoring of Vancomycin in Neonates in China

Guo Yiming; Guo Xin; Bai Fengzhi

doi:10.13407/j.cnki.jpp.1672-108X.2020.01.013

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Retrospective Analysis of Serum Concentration Monitoring of Vancomycin in Neonates in China

更新时间：2022-11-03

- Retrospective Analysis of Serum Concentration Monitoring of Vancomycin in Neonates in China
- Vol. 26, Issue 1, Pages: 39-42(2020)
- 作者机构：
  
  吉林大学中日联谊医院,吉林,长春,130033
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2020.01.013
  CLC：
- Published：2020，
  
  Published Online：10 January 2020，
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Guo Yiming, Guo Xin, Bai Fengzhi. Retrospective Analysis of Serum Concentration Monitoring of Vancomycin in Neonates in China. [J]. 26(1):39-42(2020)
DOI：

Guo Yiming, Guo Xin, Bai Fengzhi. Retrospective Analysis of Serum Concentration Monitoring of Vancomycin in Neonates in China. [J]. 26(1):39-42(2020) DOI： 10.13407/j.cnki.jpp.1672-108X.2020.01.013.

摘要

目的：分析中国新生儿万古霉素治疗药物浓度监测（TDM）现状，为临床用药提供建议。方法：检索中文数据库中国知网、万方数据、维普网，检索时限为建库至2017年12月31日，纳入新生儿万古霉素TDM文献，统计监测例次、监测依据、监测方法、给药方案、首次采血时间、谷浓度范围、不良反应。结果：纳入14篇文献，1 273例新生儿的万古霉素TDM 1 968例次。多数文献明确了以指南或专家共识作为监测依据，测定方法以高效液相色谱法为主（71.80%），92.38%的TDM采用了说明书给药方案，73.68%的TDM采用4~5个维持剂量采血；21.24%的TDM谷浓度平均值在10~20 mg/L之间，78.76%的TDM谷浓度平均值<10 mg/L，不良反应发生率为15.24%。结论：中国新生儿万古霉素TDM数量较少，且60%以上的谷浓度监测结果不在治疗范围内，加强TDM十分必要。

Abstract

Objective: To analyze the current status of therapeutic drug monitoring (TDM) of vancomycin in neonates in China

and to provide recommendations for clinical drug use. Methods: CNKI

Wanfang database

VIP were retrieved

the retrieve time was from the establishment of the database to Dec. 31st

2017. Monitoring cases

monitoring basis

monitoring method

drug administration regimen

collection time of first blood

valley concentration range and adverse drug reactions were statistically analyzed. Results: A total of 14 literature were collected

including 1

273 neonates with 1

968 cases of TDM of vancomycin. Most of the literature had been clear about the guide or expert consensus as monitoring. The determination method was mainly high performance liquid chromatography (71.80%). Totally 92.38% of TDM used the dosing regimen from the instructions

73.68% of TDM used 4 to 5 maintenance doses for blood collection. And 21.24% of TDM with average valley concentration ranged from 10 to 20 mg/L

78.76% of TDM with average valley concentration <10 mg/L. The incidence of adverse drug reactions was 15.24%. Conclusion: The number of TDM of vancomycin in neonates in China is relatively small

and the monitoring results of valley concentration above 60% are not within the scope of treatment

it is necessary to strengthen the TDM.

关键词

万古霉素血药浓度监测谷浓度新生儿

Keywords

ancomycinserum concentration monitoringalley concentrationneonates

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