Objective: To systematically evaluate the sodium valproate monotherapy on serum lipid levels in children with epilepsy. Methods: CNKI

Wanfang database

PubMed

the Cochrane Library and Embase were retrieved to collect the case-control study

cohort study and cross-sectional study. Literature was screened independently by two researchers based on inclusion and exclusion criteria. After extracting the data and evaluating the quality of the literature

the RevMan 5.3 software was used for meta-analysis. Results: Twenty literature were included in the meta-analysis

all of which were case-control studies

with a total of 586 cases in the case group and 1

155 cases in the control group. Meta-analysis showed that there were no statistically significant differences between two groups in total cholesterol [SMD=0.24

95%CI(-0.11

0.58)]

triglycerides [SMD=0.28

95%CI(-0.06

0.62)]

high-density lipoprotein [SMD=0.12

95%CI(-0.16

0.39)] and low-density lipoprotein [SMD=0

95%CI(-0.31

0.32)] (P>0.05). Conclusion: Based on current evidence

it can be concluded that sodium valproate monotherapy has no effect on serum lipid levels in children with epilepsy. However

in view of the low quality of the included literature and the small sample size

the results of this study need to be further verified by large samples and high-quality literature.