Efficacy and Prognostic Factors of First-Line Immunotherapy on Anti-N-Methyl-D Aspatate Receptor Encephalitis

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Efficacy and Prognostic Factors of First-Line Immunotherapy on Anti-N-Methyl-D Aspatate Receptor Encephalitis

更新时间：2022-11-03

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- Efficacy and Prognostic Factors of First-Line Immunotherapy on Anti-N-Methyl-D Aspatate Receptor Encephalitis
- Vol. 26, Issue 1, Pages: 10-14(2020)
- 作者机构：
  
  西安市儿童医院,陕西,西安,710000
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2020.01.004
  CLC：
- Published：2020，
  
  Published Online：10 January 2020，
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Li Dongjing, Li Xia. Efficacy and Prognostic Factors of First-Line Immunotherapy on Anti-N-Methyl-D Aspatate Receptor Encephalitis. [J]. 26(1):10-14(2020)
DOI：

Li Dongjing, Li Xia. Efficacy and Prognostic Factors of First-Line Immunotherapy on Anti-N-Methyl-D Aspatate Receptor Encephalitis. [J]. 26(1):10-14(2020) DOI： 10.13407/j.cnki.jpp.1672-108X.2020.01.004.

摘要

目的：探讨一线免疫治疗抗N-甲基-D-天冬氨酸受体（NMDAR）脑炎的疗效及预后。方法：选取2012年2月至2017年2月在西安市儿童医院住院的抗NMDAR脑炎患者63例，采用糖皮质激素联合静脉注射免疫球蛋白进行治疗，随访患者治疗后的mRS评分及复发情况，采用单因素及Logistic回归分析治疗后影响患者mRS评分及复发的危险因素。结果：采用一线免疫治疗抗NMDAR脑炎2个月后，患儿mRS评分为（1.52±0.71）分，随访1年有12.98%（8/63）患儿复发。单因素分析结果显示，mRS评分与患者首次患病年龄、伴有不自主运动、高峰mRS评分、癫痫发作、治疗起效时间有关（P<0.05），患儿复发与首次患病伴有不自主运动、高峰mRS评分、癫痫发作有关（P<0.05）。Logistic回归分析显示，mRS评分的危险因素有高峰mRS评分、伴有不自主运动、癫痫发作、治疗起效时间（P<0.05）；患者复发的危险因素有高峰mRS评分和癫痫发作（P<0.05）。结论：一线免疫治疗抗NMDAR脑炎效果明确，高峰mRS评分和癫痫发作是影响患者治疗后短期疗效及患者复发的重要危险因素。

Abstract

Objective: To probe into the efficacy and prognostic factors of first-line immunotherapy on anti-N-Methyl-D aspatate receptor encephalitis (NMDAR). Methods: Totally 63 children with anti-NMDAR admitted into Xi’an Children’s Hospital from Feb. 2012 to Feb. 2017 were extracted as the research objects. Glucocorticoid combined with intravenous immunoglobulin injection was used for treatment

the modified Rankin scale (mRS) score and recurrence of the patients were followed up after treatment. Univariate and Logistic regression were used to analyze the risk factors of mRS score and recurrence after treatment. Results: After treatment of two months by first-line immunotherapy

the mRS score was (1.52±0.71) points

and 12.98%(8/63) of the children relapsed after one year of follow-up. Univariate analysis showed that the mRS score was related to the age of children’s first onset

accompanied by involuntary exercise

peak mRS score

seizures and onset of treatment time (P<0.05)

recurrence was associated with the first onset accompanied by involuntary movement

peak mRS score and seizures (P<0.05). Logistic regression analysis showed that the risk factors for mRS score were peak mRS score

accompanied by involuntary movement

seizures

and onset of treatment time (P<0.05)

the risk factors for recurrence were peak mRS score and seizures (P<0.05). Conclusion: The first-line immunotherapy has singnificant effects of anti-NMDAR encephalitis. Peak mRS scores and seizures are important risk factors that affect the short-term efficacy and recurrence of children after treatment.

关键词

一线免疫治疗抗-NMDAR脑炎mRS评分复发危险因素

Keywords

first-line immunotherapyanti-N-Methyl-D aspatate receptor encephalitismodified Rankin scale scorerecurrencerisk factors

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