Animal Experimental Study on Pharmacodynamics of Xiao'er Zhupo Powder in the Treatment of Col

Wang Min; Li Pengfei; Li Yaqi; Ma Quantao; Wang Jingkang; Zhang Chi; Qiu Minyi; Zhang Caijuan; Yan Qizhi; Wang Ting; Zhao Baosheng

doi:10.13407/j.cnki.jpp.1672-108X.201.04.002

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Animal Experimental Study on Pharmacodynamics of Xiao'er Zhupo Powder in the Treatment of Col

更新时间：2022-11-03

- Animal Experimental Study on Pharmacodynamics of Xiao'er Zhupo Powder in the Treatment of Col
- Vol. 27, Issue 4, Pages: 4-8(2021)
- 作者机构：
  
  1. 北京中医药大学中药学院,北京,100029
  2. 香港保和堂制药有限公司,香港,999077
  3. 北京中医药大学北京中医药研究院,北京,100029
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.201.04.002
  CLC：
- Published：2021，
  
  Published Online：10 April 2021，
扫描看全文
Wang Min, Li Pengfei, Li Yaqi, et al. Animal Experimental Study on Pharmacodynamics of Xiao'er Zhupo Powder in the Treatment of Col. [J]. 27(4):4-8(2021)
DOI：

Wang Min, Li Pengfei, Li Yaqi, et al. Animal Experimental Study on Pharmacodynamics of Xiao'er Zhupo Powder in the Treatment of Col. [J]. 27(4):4-8(2021) DOI： 10.13407/j.cnki.jpp.1672-108X.201.04.002.

摘要

目的：探究小儿珠珀散治疗感冒的药物效应，为临床应用提供参考。方法：针对感冒过程中儿童可能出现的发热、咳嗽、痰多、消化不良等症状，分别利用脂多糖（LPS）致热家兔，氨水诱发小鼠咳嗽，酚红排秘法、半固体营养糊小鼠肠推进实验探究小儿珠珀散对症治疗的作用。结果：小儿珠珀散可降低小鼠耳肿胀程度、家兔体温上升幅度，延长小鼠咳嗽潜伏期，减少咳嗽次数，减少小鼠气管酚红排出量，促进小鼠胃排空，增加小鼠小肠推进率（P均<0.05）。结论：小儿珠珀散可缓解感冒过程中的多种症状。

Abstract

Objective: To probe into the pharmacodynamics of Xiao’er Zhupo powder in the treatment of cold

so as to provide reference for clinical application. Methods: In view of the symptoms such as fever

cough

phlegm and dyspepsia in children during the process of cold

the symptomatic treatment of Xiao’er Zhupo powder for children was investigated by LPS-induced fever in rabbits

ammonia-induced cough in mice

phenol red excretion method and semi-solid nutrient paste intestine propulsion experiment. Results: Xiao’er Zhupo powder could reduce the ear swelling degree of mice

decrease the temperature ascending range of rabbits

prolong the cough latency of mice

reduce the cough times and tracheal phenol red excretiona

promote the gastric emptyness of mice

and increase the intestinal propulsion rate of mice (P<0.05). Conclusion: Xiao’er Zhupo powder can relieve a variety of symptoms of cold.

关键词

小儿珠珀散感冒咳嗽发热胃肠动力

Keywords

Xiao’er Zhupo powdercolcoughfevergastrointestinal motility

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