Expression and clinicopathological significance of PCDGF and MMP-9 in squamous cell carcinoma of tongue

HUANG Chuang1; LI Jin2; LI Zhen-hua1; ZHOU Wen-wen2; ZHOU Xiao-hong1

doi:10.13406/j.cnki.cyxb.2011.09.030

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Expression and clinicopathological significance of PCDGF and MMP-9 in squamous cell carcinoma of tongue

更新时间：2024-01-17

- Expression and clinicopathological significance of PCDGF and MMP-9 in squamous cell carcinoma of tongue
- Journal of Chongqing Medical University Vol. 36, Issue 9, Pages: 1040-1043(2011)
- 作者机构：
  
  1. 重庆市肿瘤研究所头颈科
  2. 重庆市肿瘤研究所病理科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.09.030
  CLC： R739.86
- Published：2011，
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[1]黄闯,李进,李真华,周文文,周晓红.舌鳞状细胞癌中PCDGF和MMP-9蛋白的表达及临床意义[J].重庆医科大学学报,2011,36(09):1040-1043.

HUANG Chuang1, LI Jin2, LI Zhen-hua1, et al. Expression and clinicopathological significance of PCDGF and MMP-9 in squamous cell carcinoma of tongue. [J]. Journal of Chongqing Medical University 36(9):1040-1043(2011)
[1]黄闯,李进,李真华,周文文,周晓红.舌鳞状细胞癌中PCDGF和MMP-9蛋白的表达及临床意义[J].重庆医科大学学报,2011,36(09):1040-1043. DOI： 10.13406/j.cnki.cyxb.2011.09.030.

HUANG Chuang1, LI Jin2, LI Zhen-hua1, et al. Expression and clinicopathological significance of PCDGF and MMP-9 in squamous cell carcinoma of tongue. [J]. Journal of Chongqing Medical University 36(9):1040-1043(2011) DOI： 10.13406/j.cnki.cyxb.2011.09.030.

摘要

目的:探讨畸胎瘤细胞源性生长因子（PC cell-derived growth factor

PCDGF）和基质金属蛋白酶-9（Matrix metallopro-teinase-9

MMP-9）在舌鳞状细胞癌中的表达及其与临床病理参数之间的关系。方法:采用免疫组织化学方法检测45例舌鳞状细胞癌和12例正常舌组织中PCDGF和MMP-9蛋白的表达情况。结果:与正常舌组织相比

PCDGF和MMP-9蛋白在舌鳞状细胞癌中的表达明显升高（P

0.05）。PCDGF和MMP-9蛋白的表达随舌鳞状细胞癌的浸润深度增加而增加（P

0.05）

在淋巴结转移组高于无淋巴结转移组（P

0.05）

在临床Ⅲ

Ⅳ

期的表达高于临床Ⅰ

Ⅱ

的表达（P

0.05）。PCDGF和MMP-9蛋白的表达与患者年龄、性别及组织学分级无相关性（P

0.05）。PCDGF和MMP-9蛋白在舌鳞状细胞癌中的表达呈正相关r（s=0.543

0.01）。结论:PCDGF和MMP-9蛋白在舌鳞状细胞癌的发展、浸润和转移中可能起重要作用

且二者之间可能存在协同作用。

Abstract

Objective:To investigate the expressions of PC cell-derived growth factor(PCDGF) and matrix metalloproteinase-9(MMP-9) in squamous cell carcinoma of tongue(SCCT) and their relationship with clinical pathological parameters of SCCT.Methods:Immunohistochemical staining was used to examine the expressions of PCDGF and MMP-9 in 45 cases of SCCT and 12 specimens of normal tongue tissue.Results:PCDGF and MMP-9 proteins were abnormally increased in SCCT as compared with normal tongue tissue(P<0.05).PCDGF and MMP-9 protein expressions were increased with the increase in the invasive depth of SCCT(P<0.05).PCDGF and MMP-9 protein expressions were significantly higher in SCCT with nodal metastasis and at Ⅲ～Ⅳ clinical stage than those without nodal metastasis and at Ⅰ～Ⅱ clinical stage(P<0.05).The positive expressions of PCDGF and MMP-9 proteins were not related to the age

gender

and differentiation of SCCT patients(P>0.05).The Spearman analysis indicated that the expression level of PCDGF was positively correlated with that of MMP-9 significantly in SCCT(rs=0.543

P<0.01).Conclusion:PCDGF and MMP-9 may cooperate with each other and play an important role in the development

invasion and metastasis of SCCT.

关键词

舌鳞状细胞癌畸胎瘤细胞源性生长因子基质金属蛋白酶-9免疫组织化学

Keywords

squamous cell carcinoma of tonguePC cell-derived growth factor(PCDGF)matrix metalloproteinase-9(MMP-9)immunohistochemistry

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