Mixed epithelial/mesenchymal metaplastic carcinoma(carcinosarcoma)of breast:two cases report and literature review

JIANG Qing-ming; ZHOU Wen-wen; LI Jing; SONG Rong

doi:10.13406/j.cnki.cyxb.2011.09.021

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Mixed epithelial/mesenchymal metaplastic carcinoma(carcinosarcoma)of breast:two cases report and literature review

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- Mixed epithelial/mesenchymal metaplastic carcinoma(carcinosarcoma)of breast:two cases report and literature review
- Journal of Chongqing Medical University Vol. 36, Issue 9, Pages: 1143-1146(2011)
- 作者机构：
  
  重庆市肿瘤研究所病理科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.09.021
  CLC： R737.9
- Published：2011，
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[1]姜青明,周文文,李进,宋容.乳腺上皮/间叶混合型化生性癌(癌肉瘤)2例报道及文献复习[J].重庆医科大学学报,2011,36(09):1143-1146.

JIANG Qing-ming, ZHOU Wen-wen, LI Jing, et al. Mixed epithelial/mesenchymal metaplastic carcinoma(carcinosarcoma)of breast:two cases report and literature review. [J]. Journal of Chongqing Medical University 36(9):1143-1146(2011)
[1]姜青明,周文文,李进,宋容.乳腺上皮/间叶混合型化生性癌(癌肉瘤)2例报道及文献复习[J].重庆医科大学学报,2011,36(09):1143-1146. DOI： 10.13406/j.cnki.cyxb.2011.09.021.

JIANG Qing-ming, ZHOU Wen-wen, LI Jing, et al. Mixed epithelial/mesenchymal metaplastic carcinoma(carcinosarcoma)of breast:two cases report and literature review. [J]. Journal of Chongqing Medical University 36(9):1143-1146(2011) DOI： 10.13406/j.cnki.cyxb.2011.09.021.

摘要

目的:探讨乳腺上皮/间叶混合型化生性癌（癌肉瘤）的临床病理学特征、鉴别诊断、预后。方法:对我院2例乳腺上皮/间叶混合型化生性癌（癌肉瘤）进行组织病理学和免疫表型观察并复习文献加以讨论。结果:镜检显示病变边界清楚

1例由分化较差的浸润性导管癌成分及软骨肉瘤组成;另一例主要为恶性纤维组织细胞瘤

其边缘局灶见导管原位癌成分。免疫表型:例1间叶成分vimentin

S-100阳性

CK阴性;浸润性导管癌CK阳性

C-erbB-2均阴性;例2间叶成分vimentin

CD68

AACT阳性

上皮性标记

包括CK-pan

P63

CK-low

CK7

CK19

CK5/6

CK34βE12均阴性

导管原位癌CK阳性

C-erbB-2均阴性。结论:原发于乳腺的上皮/间叶混合型化生性癌（癌肉瘤）较罕见

诊断需与乳腺原发性肉瘤、恶性叶状肿瘤、肉瘤化癌、促纤维增生性乳腺癌相鉴别。

Abstract

Objective:To investigate the clinical and pathological features

diagnosis and prognosis of breast mixed epithelial/mesenchymal metaplastic carcinoma(carcinosarcoma).Methods:The histopathology and immune phenotype of two cases of breast carcinosarcoma in our hospital were observed

studied and discussed

and related literatures were reviewed.Results:Microscopic examination showed that pathological changes were well-demarcated.One case was poorly differentiated invasive ductal carcinoma and chondrosarcoma component;the major component of the other case was malignant fibrous histocytoma

and a few ductal carcinoma in situ were observed on the edge of the lesion.Immunohistochemically

the chondrosarcoma cells of the first case were positive for Vimentin and S-100

negative for CK

the carcinoma cells were positive for CK

negative for ER

PR and C-erbB-2

the sarcoma cells of the second case were positive for Vimentin

CD68 and AACT

negative for CK-pan

P63

CK-low

CK7

CK19

CK5/6 and CK34βE12

the carcinoma cells in situ were positive for CK-pan

negative for ER

PR and C-erbB-2.Conclusion:The primary mixed epithelial/mesenchymal metaplastic carcinoma(carcinosarcoma)in the breast gland was rare

whose diagnosis should be differentiated with the primary sarcoma

malignant phyllodes tumor

carcinoma sarcomatodes

promoting fiber hyperplastic cancer in the breast.

关键词

乳腺肿瘤化生性癌癌肉瘤诊断鉴别

Keywords

mammary neoplasmmetaplastic carcinomacarcinosarcomadiagnosisdifferentiation

references

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Related Institution

Department of Radiology，The First Affiliated Hospital of Chongqing Medical University

Teaching and Research Section of Pathology，College of Basic Medical Sciences，Chongqing Medical University

Department of Traditional Chinese Medicine，Children’s Hospital，Zhejiang University School of Medicine/ National Clinical Research Center for Child Health

Department of Pediatrics，The Affiliated Hospital of Nanjing University of Chinese Medicine，The First Clinical Medical College of Nanjing University of Chinese Medicine

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