Research on effect of chitosan-polylactic acid film on rabbit colonic fistula for primary repair

ZENG Zhi-hua1; CHEN Kang2; LI Ying2; XIE Liang-xian2

doi:10.13406/j.cnki.cyxb.2011.09.017

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Research on effect of chitosan-polylactic acid film on rabbit colonic fistula for primary repair

更新时间：2024-01-17

- Research on effect of chitosan-polylactic acid film on rabbit colonic fistula for primary repair
- Journal of Chongqing Medical University Vol. 36, Issue 9, Pages: 1057-1059(2011)
- 作者机构：
  
  1. 重庆医科大学中医药学院针灸教研室
  2. 解放军三二四医院普外科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.09.017
  CLC： R656.9
- Published：2011，
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[1]曾志华,陈康,李瑛,谢良宪.壳聚糖聚乳酸膜的兔结肠瘘一期修复实验研究[J].重庆医科大学学报,2011,36(09):1057-1059.

ZENG Zhi-hua1, CHEN Kang2, LI Ying2, et al. Research on effect of chitosan-polylactic acid film on rabbit colonic fistula for primary repair. [J]. Journal of Chongqing Medical University 36(9):1057-1059(2011)
[1]曾志华,陈康,李瑛,谢良宪.壳聚糖聚乳酸膜的兔结肠瘘一期修复实验研究[J].重庆医科大学学报,2011,36(09):1057-1059. DOI： 10.13406/j.cnki.cyxb.2011.09.017.

ZENG Zhi-hua1, CHEN Kang2, LI Ying2, et al. Research on effect of chitosan-polylactic acid film on rabbit colonic fistula for primary repair. [J]. Journal of Chongqing Medical University 36(9):1057-1059(2011) DOI： 10.13406/j.cnki.cyxb.2011.09.017.

摘要

目的:研究壳聚糖聚乳酸膜（Chitosan-polylactic acid film

CPAF）对兔结肠瘘的一期治疗效果。方法:制备聚乳酸膜（Polylactic acid film

PAF）和CPAF。新西兰大耳白兔24只

均分3组予以不同的处理（PAF组、CPAF组、对照组）

结肠造瘘后荷包缝合

其中PAF组予以PAF覆盖缝合

CPAF组予以CPAF覆盖缝合

对照组不作其他处理

平行观察

20 d后处死动物作免疫组化检测转移生长因子β1（Transforming growth factor

TGF-β1）。结果:PAF和CPAF的物理特性无统计学差异。PAF组和CPAF组动物全部存活

对照组动物7 d内死亡。TGF-β1免疫组化染色CPAF组明显少于PAF组和对照组

PAF组明显少于对照组

结果有统计学差异。CPAF组对TGF-β1的抑制作用强于PAF组和对照组

结果差异显著。结论:CPAF对兔结肠瘘的一期治疗效果优于PAF。

Abstract

Objective:To compare therapeutic effects of chitosan-polylactic acid film on rabbit colonic fistula.Methods:Polylactic acid film(PAF) and chitosan-polylactic acid film(CPAF) were prepared.The rabbits were divided equally into three groups for different treatments(PAF group

CPAF group

control group)

purse string suture following colon stoma.After such disposition

PAF group and CPAF group covered the suture with PAF and CPAF respectively

while control group did nothing.Rabbits were parallel observed and detected with immunohistochemical staining for TGF-β1 after 20 days.Results:Physical characteristic had no statistics difference between PAF and CPAF.Rabbits in PAF and CPAF group all survived

but in control group were dead within 7 days.Immunohistochemical staining for TGF-β1 had obviously smaller amount in CPAF than in PAF and control group

and PAF also smaller than control group.Statistics difference was observed.CPAF had more inhibition in TGF-β1 than the other two group and the results were significant difference.Conclusion:CPAF had better therapeutic efficacy than PAF on colonic fistula.

关键词

聚乳酸壳聚糖结肠瘘

Keywords

polylactic acidchitosancolonic

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Related Institution

Department of Cardiovascular Medicine,the Children’s Hospital,Chongqing Medical University

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China International Science and Technology Cooperation Base of Child Development and Critical Disorders,Chongqing Key Laboratory of Pediatrics,Ministry of Education Key Laboratory of Child Development and Disorders,the Children’s Hospital,Chongqing Medical University

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