Nonalcoholic fatty liver disease increases the risk of cholecystolithiasis

LIU Ying; ZHANG Chi; WANG Min; XIONG Pu; CHEN Jing; WANG Xia; LI Hua-zhu; YANG Xiao-chun; ZHOU Gui-lian

doi:10.13406/j.cnki.cyxb.2011.09.015

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Nonalcoholic fatty liver disease increases the risk of cholecystolithiasis

更新时间：2024-01-17

- Nonalcoholic fatty liver disease increases the risk of cholecystolithiasis
- Journal of Chongqing Medical University Vol. 36, Issue 9, Pages: 1122-1124(2011)
- 作者机构：
  
  湖南省人民医院内分泌科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.09.015
  CLC： R575.5
- Published：2011，
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[1]刘瑛,张弛,王敏,熊璞,陈晶,王霞,李华珠,杨晓春,周桂莲.非酒精性脂肪性肝病增加胆囊结石患病风险[J].重庆医科大学学报,2011,36(09):1122-1124.

LIU Ying, ZHANG Chi, WANG Min, et al. Nonalcoholic fatty liver disease increases the risk of cholecystolithiasis. [J]. Journal of Chongqing Medical University 36(9):1122-1124(2011)
[1]刘瑛,张弛,王敏,熊璞,陈晶,王霞,李华珠,杨晓春,周桂莲.非酒精性脂肪性肝病增加胆囊结石患病风险[J].重庆医科大学学报,2011,36(09):1122-1124. DOI： 10.13406/j.cnki.cyxb.2011.09.015.

LIU Ying, ZHANG Chi, WANG Min, et al. Nonalcoholic fatty liver disease increases the risk of cholecystolithiasis. [J]. Journal of Chongqing Medical University 36(9):1122-1124(2011) DOI： 10.13406/j.cnki.cyxb.2011.09.015.

摘要

目的:探讨胆囊结石与非酒精性脂肪性肝病（Nonalcoholic fatty liver disease

NAFLD）的关系。方法:选择2006年4月7日-2010年1月9日湖南省人民医院体检个体共4 076例

排除过量饮酒、乙肝标志物阳性、严重感染及代谢综合征（Metabolicsyndrome

MS）资料不全者

共2830例纳入研究

其中1 367例在1～3年后再次体检。记录肝脏B超结果。结果:①体检人群中

胆囊结石患者合并NAFLD患病率明显高于非胆囊结石患者（43.20%vs 33.76%

P<0.05）

NAFLD患者合并胆囊结石患病率亦明显高于非NAFLD患者（11.03%vs 7.67%

P<0.05）;②随访1～3年后

NAFLD组（n=430）的胆囊结石发病率高于非NFALD组n（=834）（3.72%vs 1.68%

P<0.05）

NAFLD发生胆囊结石的OR值为2.264（95%CI

1.094-4.683;P<0.05）。结论:①胆囊结石与NAFLD易合并存在。②NAFLD可增加胆囊结石患病风险。

Abstract

Objective:To investigate the relationship between nonalcoholic fatty liver disease(NAFLD) and cholecystolithiasis.Methods:Ultrasonography was used to diagnose NAFLD in 4 076 subjects attending routine health examination in the People’s Hospital of Hunan Province from April 2006 to January 2010.Total 2 830 subjects were enrolled in this study excluding those with excessive drinking

hepatitis B markers

and severe infection

and whose data to diagnose metabolic syndrome were missing.There were 1367 patients who received the routine health examination again during 3 years.The result of ultrasonography was recorded.Results: ①In the subjects undergoing routine health examination in People’s Hospital of Hunan Province

the prevalence of NAFLD in patients with cholecystolithiasis was significantly higher than that in those without cholecystolithiasis(43.20% vs 33.76%

P<0.05).Similarly

the prevalence of cholecystolithiasis in patients with NAFLD was also higher than that in those without NAFLD(11.03% vs.7.67%

P<0.05).②In a following up of 1 367 patients for 1 to 3 years

we found that the morbidity of cholecystolithiasis in patients with NAFLD(n=430) was significantly higher than that in those without NAFLD(n=430)(3.72% vs.1.68%

P<0.05).The presence of NAFLD was associated with an increased risk of cholecystolithiasis(OR=2.264;95% CI

1.094-4.683;P<0.05).Conclusion:①Cholecystolithiasis and NAFLD frequently coexist.②NAFLD may increase the risk of cholecystolithiasis.

关键词

胆囊结石非酒精性脂肪性肝病胰岛素抵抗

Keywords

cholecystolithiasisnonalcoholic fatty liver diseaseinsulin resistance

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