Genetic polymorphism of seventeen Y-chromosomeal STR loci in XinJiang Bazhou Uygur population

CHEN Hui-jin 1; PU Hong-wei 2; HU Jia3; WANG Wei3; ZHANG Li-ping1

doi:10.13406/j.cnki.cyxb.2011.09.005

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Genetic polymorphism of seventeen Y-chromosomeal STR loci in XinJiang Bazhou Uygur population

更新时间：2024-01-17

- Genetic polymorphism of seventeen Y-chromosomeal STR loci in XinJiang Bazhou Uygur population
- Journal of Chongqing Medical University Vol. 36, Issue 9, Pages: 1060-1062(2011)
- 作者机构：
  
  1. 新疆医科大学基础医学院生物化学与分子生物学教研室
  2. 新疆医科大学基础医学院病理教研室
  3. 新疆巴州公安局刑科所
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.09.005
  CLC： R394
- Published：2011，
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[1]陈慧锦,蒲红伟,胡佳,王伟,张丽萍.新疆巴州维吾尔族17个Y-STR位点遗传多态性[J].重庆医科大学学报,2011,36(09):1060-1062.

CHEN Hui-jin 1, PU Hong-wei 2, HU Jia3, et al. Genetic polymorphism of seventeen Y-chromosomeal STR loci in XinJiang Bazhou Uygur population. [J]. Journal of Chongqing Medical University 36(9):1060-1062(2011)
[1]陈慧锦,蒲红伟,胡佳,王伟,张丽萍.新疆巴州维吾尔族17个Y-STR位点遗传多态性[J].重庆医科大学学报,2011,36(09):1060-1062. DOI： 10.13406/j.cnki.cyxb.2011.09.005.

CHEN Hui-jin 1, PU Hong-wei 2, HU Jia3, et al. Genetic polymorphism of seventeen Y-chromosomeal STR loci in XinJiang Bazhou Uygur population. [J]. Journal of Chongqing Medical University 36(9):1060-1062(2011) DOI： 10.13406/j.cnki.cyxb.2011.09.005.

摘要

目的:调查17个Y染色体短串联重复序列（Y-Short tandem repeat

Y-STR）基因座及其单倍型在新疆巴州维吾尔族人群中的分布情况。方法:应用AmpFlSTR YfilerTM荧光标记复合扩增系统

对149名维吾尔族无关男性个体血样进行17个Y-STR位点的复合扩增

用ABI 3130XL遗传分析仪对扩增产物进行检测分析。结果:DYS456、DYS389Ⅰ/Ⅱ、DYS390、DYS458、DYS19、DYS385a/b、DYS393、DYS391、DYS439、DYS635、DYS392、Y-GATA-H4、DYS437、DYS438、DYS448各位点遗传多样性（Genetic diversity

GD）值分布在0.498 2～0.948 5之间;17个Y-STR位点共观察到单倍型148种

其单倍型多样性（Haplo-type diversity

HD）值为0.999 86。结论:新疆巴州维吾尔族17个Y-STR位点具有丰富的遗传多样性

可为父权鉴定和父系进化研究提供有价值的遗传学资料。

Abstract

Objective:To investigate the allelic and haplotype frequency distribution of seventeen short tandem repeat loci of Y chromosome in Xinjiang Uygur population in Bazhou.Methods:The template DNAs were extracted from blood samples of 149 unrelated Uygur male individuals

and seventeen Y-STR loci were amplified by the AmpFlSTR YfilerTM.The PCR products were analyzed and genotyped with ABI3130XL Sequencer.Results:The values of genetic diversity of DYS456

DYS389Ⅰ/Ⅱ

DYS390

DYS458

DYS19

DYS385a/b

DYS393

DYS391

DYS439

DYS635

DYS392

Y-GATA-H4

DYS437

DYS438

and DYS448 were between 0.4 982 and 0.9 485.A total of 148 different haplotypes were observed

and the value of genetic diversity of haplotypes was 0.99 986.Conclusion:The 17 Y-STR loci in Xinjiang Uygur population in Bazhou are highly polymorphic and suitable for paternity testing and paternal genetic lineage evolution.

关键词

Y染色体短串联重复序列维吾尔族遗传多态性

Keywords

Y chromosomeshort tandem repeatUygurgenetic polymorphism

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