Antitumor effect of grateloupia filicina on U87 cell and its xenografts in nude mice

ZHANG Zhi-ye

doi:10.13406/j.cnki.cyxb.2011.09.004

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Antitumor effect of grateloupia filicina on U87 cell and its xenografts in nude mice

更新时间：2024-01-17

- Antitumor effect of grateloupia filicina on U87 cell and its xenografts in nude mice
- Journal of Chongqing Medical University Vol. 36, Issue 9, Pages: 1051-1053(2011)
- 作者机构：
  
  河南科技大学第一附属医院肿瘤科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.09.004
  CLC： R285.5
- Published：2011，
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[1]张治业.蜈蚣藻多糖对人神经胶质瘤U87细胞及其裸鼠移植瘤生长的抑制作用[J].重庆医科大学学报,2011,36(09):1051-1053.

ZHANG Zhi-ye. Antitumor effect of grateloupia filicina on U87 cell and its xenografts in nude mice. [J]. Journal of Chongqing Medical University 36(9):1051-1053(2011)
[1]张治业.蜈蚣藻多糖对人神经胶质瘤U87细胞及其裸鼠移植瘤生长的抑制作用[J].重庆医科大学学报,2011,36(09):1051-1053. DOI： 10.13406/j.cnki.cyxb.2011.09.004.

ZHANG Zhi-ye. Antitumor effect of grateloupia filicina on U87 cell and its xenografts in nude mice. [J]. Journal of Chongqing Medical University 36(9):1051-1053(2011) DOI： 10.13406/j.cnki.cyxb.2011.09.004.

摘要

目的:研究蜈蚣藻多糖对人神经胶质瘤U87细胞及其裸鼠移植瘤生长的抑制作用。方法:体外培养U87细胞

MTT法观察蜈蚣藻多糖其生长抑制作用。构建人神经胶质瘤U87细胞裸鼠移植瘤模型

将裸鼠随机分成5组

蜈蚣藻多糖3个剂量隔天尾静脉注射

观察相对肿瘤体积、相对肿瘤增殖率、抑瘤率

以此评价蜈蚣藻多糖的抗肿瘤作用。结果:蜈蚣藻多糖能够抑制人神经胶质瘤U87细胞的生长;对移植了U87细胞的裸鼠尾静脉注射蜈蚣藻多糖1、5 mg/kg和25 mg/kg

28 d后其抑瘤率分别为27.02%、39.93%、58.11%。结论:蜈蚣藻多糖具有体内外抗肿瘤活性。

Abstract

Objective:To investigate the inhibitory effect of grateloupia filicina on U87 cell and its xenografts in nude mice.Methods:The potential effect of grateloupia filicina on the cell viability was examined using MTT assay.U87 cells were inoculated into the nude mice to establish U87 cancer model.Then the nude mice with xenograft tumor were randomized into five groups.The grateloupia filicina was administered at three dosages on alternate days by vena caudalis.The anti-tumor effect of grateloupia filicina was evaluated based on the relative tumor volume

relative tumor proliferative rate and tumor inhibition rate.Results:Grateloupia filicina strongly inhibited the U87 cell growth.At the 1

5 mg/kg and 25 mg/kg dosages of grateloupia filicina for 28 d

the growth inhibition of the transplanted tumor was 27.02%

39.93%

and 58.11%

respectively.Conclusion:Grateloupia filicina inhibits the growth of human U87 cancer cell in vitro and in vivo.

关键词

蜈蚣藻多糖裸鼠U87细胞

Keywords

grateloupia filicinanude mouseU87 cell

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