Clinical and pathological patterns of infratentorial brain tumors in children

JI Wen-yuan; LIANG Ping; LI Lu-sheng; ZHAI Xuan; ZHOU Yu-dong

doi:10.13406/j.cnki.cyxb.2011.08.031

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Clinical and pathological patterns of infratentorial brain tumors in children

更新时间：2024-01-17

- Clinical and pathological patterns of infratentorial brain tumors in children
- Journal of Chongqing Medical University Vol. 36, Issue 8, Pages: 982-984(2011)
- 作者机构：
  
  重庆医科大学附属儿童医院神经外科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.08.031
  CLC： R739.41
- Published：2011，
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[1]纪文元,梁平,李禄生,翟瑄,周渝冬.儿童幕下肿瘤的临床治疗及病理特点[J].重庆医科大学学报,2011,36(08):982-984.

JI Wen-yuan, LIANG Ping, LI Lu-sheng, et al. Clinical and pathological patterns of infratentorial brain tumors in children. [J]. Journal of Chongqing Medical University 36(8):982-984(2011)
[1]纪文元,梁平,李禄生,翟瑄,周渝冬.儿童幕下肿瘤的临床治疗及病理特点[J].重庆医科大学学报,2011,36(08):982-984. DOI： 10.13406/j.cnki.cyxb.2011.08.031.

JI Wen-yuan, LIANG Ping, LI Lu-sheng, et al. Clinical and pathological patterns of infratentorial brain tumors in children. [J]. Journal of Chongqing Medical University 36(8):982-984(2011) DOI： 10.13406/j.cnki.cyxb.2011.08.031.

摘要

目的:探讨儿童幕下肿瘤的诊治经验

以利于早期诊断、合理治疗、改善预后。方法:对2003年7月-2009年12月间我科收治的儿童幕下肿瘤91例进行回顾性分析。结果:病理类型前3位依次是:髓母细胞瘤33例（36.3%）

星形细胞瘤28例（30.8%）

室管膜瘤21例（23.1%）。主要临床表现为呕吐、头痛、共济失调

其中首诊误诊率达31.8%。影像学检查发现不同程度梗阻性脑积水71例（78.4%）。CT阳性率94.2%

MRI阳性率100%。肿瘤全切除81例（89.0%）

次全切除6例（6.6%）

大部分切除4例（4.4%）

84例术后临床治愈出院

其中术后行放射治疗41例

占45.0%

化疗30例

占32.9%。结论:儿童后颅窝肿瘤临床表现不典型

病程短

多合并脑积水

误诊率较高

头颅计算机断层扫描（Computed tomography

CT）和核磁共振成像（Magneticresonance imaging

MRI）是诊断的首选方法。手术是治疗的第一选择

积极处理脑积水和并发症有利于改善患者预后。术后进行放化疗

对于延长儿童的生存期是有效的。

Abstract

Objective:To explore the experience of the diagnosis and treatment of infratentorial tumors in children

in order to make early diagnosis

get reasonable treatment and improve prognosis.Methods:91 cases from July 2003 to December 2009 with infratentorial tumors admitted into children’s hospital of Chongqing medical university were analyzed retrospectively.Results:29 cases(31.8%)were misdiagnosed.The top three of tumors were medulloblastoma(33 cases

36.3%)

astrocytoma(28 cases

30.8%)

and ependymoma(21 cases

23.1%).The main clinical manifestations were vomiting

headache

and incoordination.Obstructive hydrencephalus was found in 71 cases(78.4%) by imaging examination.Positive rate of tumors diagnosis was 94.2% and 100% by brain CT and MRI scanning

respectively.Total resection was achieved in 81 cases(89.01%);subtotal resection in 6 cases(6.6%);partial resection in 4 cases(4.39%)

and clinical cure in 84 cases.After operation

41 received radiotherapy(45.0%)and 30 received chemotherapy(32.9%).Conclusion:Children’s infratentorial tumors have atypical clinical manifestations and short course of diseases and hydrocephalu.It is common to be misdiagnosed.Brain MRI and CT are the initial choice in the diagnosis.Surgical resection is the first selection to cure intracranial tumor in childhood.Positive treatment of hydrocephalus and postoperative complications is beneficial to improve the surgical outcome.After operation

individual radiotherapy and chemotherapy are helpful for longer survival.

关键词

幕下肿瘤儿童临床特征病理

Keywords

infratentorial tumorschildclinical characteristicpathology

references

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