Comparison of the associations of ApoB/ApoA1 ratio and high-sensitive C-reactive protein with insulin resistance

WANG Bang-qiong1; LUO Rong2; LI Qi-fu1; JIANG Yuan-juan1; LIU Zhou-jun1; ZHONG Li1; CHENG Qing-feng1; QING Hua1

doi:10.13406/j.cnki.cyxb.2011.08.022

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Comparison of the associations of ApoB/ApoA1 ratio and high-sensitive C-reactive protein with insulin resistance

更新时间：2024-01-17

- Comparison of the associations of ApoB/ApoA1 ratio and high-sensitive C-reactive protein with insulin resistance
- Journal of Chongqing Medical University Vol. 36, Issue 8, Pages: 900-903(2011)
- 作者机构：
  
  1. 重庆医科大学附属第一医院内分泌科
  2. 重庆医科大学附属第一医院体检中心
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.08.022
  CLC： R587
- Published：2011，
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[1]王邦琼,罗蓉,李启富,蒋袁娟,刘洲君,钟立,程庆丰,青华.ApoB/ApoA1比值和hs-CRP与胰岛素抵抗的相关性研究[J].重庆医科大学学报,2011,36(08):900-903.

WANG Bang-qiong1, LUO Rong2, LI Qi-fu1, et al. Comparison of the associations of ApoB/ApoA1 ratio and high-sensitive C-reactive protein with insulin resistance. [J]. Journal of Chongqing Medical University 36(8):900-903(2011)
[1]王邦琼,罗蓉,李启富,蒋袁娟,刘洲君,钟立,程庆丰,青华.ApoB/ApoA1比值和hs-CRP与胰岛素抵抗的相关性研究[J].重庆医科大学学报,2011,36(08):900-903. DOI： 10.13406/j.cnki.cyxb.2011.08.022.

WANG Bang-qiong1, LUO Rong2, LI Qi-fu1, et al. Comparison of the associations of ApoB/ApoA1 ratio and high-sensitive C-reactive protein with insulin resistance. [J]. Journal of Chongqing Medical University 36(8):900-903(2011) DOI： 10.13406/j.cnki.cyxb.2011.08.022.

摘要

目的:比较载脂蛋白B（Apolipoprotein B

ApoB）/载脂蛋白A1（Apolipoprotein A1

ApoA1）比值（ApoB/ApoA1比值）和超敏C反应蛋白（High sensitive C-reactive protein

hs-CRP）与胰岛素抵抗（Insulin resistance

IR）的相关性。方法:纳入426例非糖尿病个体

测定体重、身高、血压、腰围、空腹血浆葡萄糖（Fasting plasma glucose

FPG）、血清胰岛素（Fasting insulin

Fins）、血脂和hs-CRP等

计算IR指数（HOMA-IR）

并以HOMA-IR上四分位为切点分为IR组与非IR组。结果:IR人群ApoB/ApoA1比值和hs-CRP较非IR人群有显著差异（P

0.01）。校正性别、年龄和腰围后

线性回归分析发现ApoB/ApoA1比值仍是HOMA-IR的主要影响因素[B（95%CI）:0.27（0.06

.48）

P=0.013];而hs-CRP与HOMA-IR的关系无统计学意义。控制性别、年龄后

高ApoB/ApoA1比值人群发生IR的危险较低ApoB/ApoA1比值人群增加2.17倍[OR（95%CI）:2.17（1.33

.54）

P=0.002]

而高hs-CRP人群发生IR的危险较低hs-CRP人群增加1.78倍[OR（95%CI）:1.78（1.09-2.92）

P=0.021]

。结论:在非糖尿病人群中

与hs-CRP相比

ApoB/ApoA1比值是更好的IR预测指标。

Abstract

Objective:To compare the associations of Apolipoprotein B/Apolipoprotein A1 ratio(ApoB/ApoA1 ratio) and high sensitive C-reactive protein(hs-CRP) with insulin resistance(IR).Methods:426 non-diabetes Chinese were recruited.Weight

height

blood pressure

waist circumference

fasting plasma glucose(FPG)

fasting serum insulin(Fins)

blood lipids and hs-CRP were measured.HOMA index(HOMA-IR) was calculated.IR was defined as the upper quartile of HOMA-IR.Results:ApoB/ApoA1 ratio and hs-CRP were significantly higher in subjects with IR compared with subjects without(P<0.01).After adjustment for age

gender and waist circumference

line regression analysis found that ApoB/ApoA1 ratio was still the main influence factor of HOMA-IR [B(95%CI):0.27(0.06-0.48)

P=0.013];However

the partial regression coefficient of hs-CRP and HOMA-IR was no longer statistically significant.Compared to the subjects with low ApoB/ApoA1 ratio

those with high ApoB/ApoA1 ratio were 2.17 [OR(95%CI):2.17(1.33-3.54)

P=0.002] times more likely to be with IR;and Compared to the subjects with low hs-CRP

those with high hs-CRP were [OR(95%CI):1.78(1.09-2.92)

P=0.021] times more likely to be with IR.Conclusion:compared with hs-CRP

ApoB/ApoA1 ratio might be a better marker of IR in non-diabetic Chinese population.

关键词

载脂蛋白B/载脂蛋白A1比值超敏C反应蛋白胰岛素抵抗

Keywords

apolipoprotein B/apolipoprotein A1 ratiohigh sensitive C-reactive proteininsulin resistance

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