Serum levels and clinical significance of IL-17,IL-23 in chronic obstructive pulmonary disease

LIU Ren-jie1; WAN Yi-xin2; WANG Xiao-ping2; SHI Jun-nian2; DUAN Tian-lin1; LI Jing-zhao1

doi:10.13406/j.cnki.cyxb.2011.08.020

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Serum levels and clinical significance of IL-17,IL-23 in chronic obstructive pulmonary disease

更新时间：2024-01-17

- Serum levels and clinical significance of IL-17,IL-23 in chronic obstructive pulmonary disease
- Journal of Chongqing Medical University Vol. 36, Issue 8, Pages: 976-978(2011)
- 作者机构：
  
  1. 许昌市中心医院呼吸科
  2. 兰州大学第二医院呼吸科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.08.020
  CLC： R563.9
- Published：2011，
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[1]刘仁杰,万毅新,王晓平,石军年,段天林,李景钊.慢性阻塞性肺疾病患者血清IL-17、IL-23水平及临床意义[J].重庆医科大学学报,2011,36(08):976-978.

LIU Ren-jie1, WAN Yi-xin2, WANG Xiao-ping2, et al. Serum levels and clinical significance of IL-17,IL-23 in chronic obstructive pulmonary disease. [J]. Journal of Chongqing Medical University 36(8):976-978(2011)
[1]刘仁杰,万毅新,王晓平,石军年,段天林,李景钊.慢性阻塞性肺疾病患者血清IL-17、IL-23水平及临床意义[J].重庆医科大学学报,2011,36(08):976-978. DOI： 10.13406/j.cnki.cyxb.2011.08.020.

LIU Ren-jie1, WAN Yi-xin2, WANG Xiao-ping2, et al. Serum levels and clinical significance of IL-17,IL-23 in chronic obstructive pulmonary disease. [J]. Journal of Chongqing Medical University 36(8):976-978(2011) DOI： 10.13406/j.cnki.cyxb.2011.08.020.

摘要

目的:探讨白介素-17（Interleukin-17

IL-17）、白介素-23（Interleukin-23

IL-23）在慢性阻塞性肺疾病（Chronic ob-structive pulmonary disease

COPD）发病过程中的临床意义。方法:采用酶联免疫吸附试验（ELISA）法测定慢性阻塞性肺疾病急性加重期（Acute exacerbations of COPD

AECOPD）组、COPD稳定期组（治疗前后）各30人及健康体检者（健康对照组）30人血清IL-17、IL-23浓度;血常规中性粒细胞（N）百分比（%）、肺功能第一秒用力呼气容积占预计值百分比（FEV1%）由检验科及肺功能室测定。结果:①AECOPD、COPD稳定期及健康对照组血清IL-17、IL-23各组间比较差异具有统计学意义（P<0.05）;②AE-COPD与COPD稳定期组、健康对照组外周血N（%）组间比较差异具有统计学意义（P<0.05）;③AECOPD、COPD稳定期组及健康对照组FEV1%组间比较差异具有统计学意义（P<0.05）;④所有COPD患者血清中IL-23与IL-17呈直线正相关（r=0.449

P=0.000<0.001）;⑤所有COPD患者血清中IL-17与N（%）呈直线相关（r=0.273

P=0.035<0.05）;⑥所有研究对象血清中IL-17与FEV1%呈直线负相关（r=-0.510

P=0.000<0.001）。结论:IL-17、IL-23与COPD的炎症过程及临床表现具有一定的相关性。

Abstract

Objective:To investigate serum levels and clinical significance of IL-17

IL-23 in chronic obstructive pulmonary disease(COPD).Methods:Serum IL-17 and IL-23 levels were detected in 90 subjects including 60 COPD(30 acute exacerbation and 30 stable) and 30 healthy controls by ELISA.The percentage of blood neutrophils N(%) and the percentage of forced expiratory volume in one second of predicted value(FEV1%) were measured respectively by the department of Clinical Laboratory and the Lung Function Laboratory of Lanzhou University Second Hospital.Results:①IL-17 and IL-23 serum levels were significantly different(P<0.05) among AECOPD

stable phase COPD and healthy controls;②N(%) was statistically significant between AECOPD and stable phase COPD(P<0.05) as well as between AECOPD and healthy controls(P<0.05);③FEV1% was statistically significant(P<0.05) among AECOPD

stable phase COPD and healthy controls;④There was a linear correlation between serum IL-17 and IL-23 in all COPD patients(r=0.449

P=0.000<0.001);⑤There was a linear correlation between serum IL-17 levels and N(%) in all COPD patients(r =0.273

P=0.035<0.05);⑥There was a negative linear correlation between IL-17 serum levels and FEV1% in all subjects(r=-0.510

P=0.000<0.001).Conclusion:IL-17 and IL-23 serum levels might be associated with inflammation in COPD and have some relevance to COPD clinical manifestations.

关键词

慢性阻塞性肺疾病IL-17IL-23

Keywords

COPDIL-17IL-23

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