The diagnostic significance of the combined detection of serum CEA,CA50,CA19-9 and CA125 in patients with obstructive jaundice from tumors

CHEN Sheng-kai; HE Shi-ju

doi:10.13406/j.cnki.cyxb.2011.07.034

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The diagnostic significance of the combined detection of serum CEA,CA50,CA19-9 and CA125 in patients with obstructive jaundice from tumors

更新时间：2024-01-17

- The diagnostic significance of the combined detection of serum CEA,CA50,CA19-9 and CA125 in patients with obstructive jaundice from tumors
- Journal of Chongqing Medical University Vol. 36, Issue 7, Pages: 842-845(2011)
- 作者机构：
  
  重庆市第三人民医院肝胆外科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.07.034
  CLC： R730.4
- Published：2011，
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[1]陈圣开,何世举.CEA、CA50、CA19-9和CA125联合检测在肿瘤性梗阻性黄疸诊断中的意义[J].重庆医科大学学报,2011,36(07):842-845.

CHEN Sheng-kai, HE Shi-ju. The diagnostic significance of the combined detection of serum CEA,CA50,CA19-9 and CA125 in patients with obstructive jaundice from tumors. [J]. Journal of Chongqing Medical University 36(7):842-845(2011)
[1]陈圣开,何世举.CEA、CA50、CA19-9和CA125联合检测在肿瘤性梗阻性黄疸诊断中的意义[J].重庆医科大学学报,2011,36(07):842-845. DOI： 10.13406/j.cnki.cyxb.2011.07.034.

CHEN Sheng-kai, HE Shi-ju. The diagnostic significance of the combined detection of serum CEA,CA50,CA19-9 and CA125 in patients with obstructive jaundice from tumors. [J]. Journal of Chongqing Medical University 36(7):842-845(2011) DOI： 10.13406/j.cnki.cyxb.2011.07.034.

摘要

目的:探讨肿瘤标志物CEA、CA50、CA19-9和CA125联合检测在肿瘤性梗阻性黄疸诊断中的意义。方法:分析我科2004年1月-2011年1月151例梗阻性黄疸患者的有关临床资料。资料分为肿瘤组（74例）和良性疾病组（77例）。结果:CEA和CA125检测值在肿瘤组明显高于良性疾病组（P<0.05）。CEA、CA50、CA19-9和CA125在肿瘤组的敏感性分别为:27.40%、62.86%、59.46%和21.43%

与良性疾病组比较差异无统计学意义（P>0.05）。CEA大于参考值上限2倍的敏感性在肿瘤组明显高于良性疾病组

分别为13.70%和2.60%（P<0.05）。CEA、CA50、CA19-9 3项联合检测同时2项以上异常的敏感性在肿瘤组明显高于良性疾病组

分别为57.97%和40.54%（P<0.05）

特异性59.46%

准确性58.74%

阳性预测值57.14%

阳性似然比1.43。CEA、CA50、CA19-9和CA125 4项联合检测同时3项以上异常的敏感性在肿瘤组明显高于良性疾病组

分别为34.14%和5.88%（P<0.05）

特异性94.12%

准确性61.33%

阳性预测值87.5%

阳性似然比5.81。CEA、CA50、CA19-9和CA125的ROC曲线A值分别为:0.597、0.575、0.573和0.646。结论:CEA、CA50、CA19-9和CA125对肿瘤性梗阻性黄疸诊断价值较低。CEA大于参考值上限2倍以上或CEA、CA50和CA19-9 3项联合检测出现2项以上异常或CEA、CA50、CA19-9和CA125 4项联合检测出现3项以上异常提示肿瘤可能性大。且在特异性、阳性预测值和阳性似然比方面

以上"4项"联合检测出现3项以上异常优于以上"3项"联合检测出现2项以上异常。

Abstract

Objective:To explore the diagnostic significance of combined detection of serum CEA

CA50

CA19-9 and CA125 in patients with obstructive jaundice from tumors.Methods:The clinical data of 151 patients with obstructive jaundice from January 2004 to January 2011 were analyzed.The clinical data were divided into tumors group(74 cases)and non-tumors group(77 cases).Results:The level of CEA and CA125 was higher in tumors group than in non-tumors group(P<0.05).The sensitivities of CEA、CA50、CA19-9 and CA125 in tumors group were 27.40%

62.86%

59.46% and 21.43% respectively

which were not higher than in non-tumors group(P>0.05).The sensitivity of CEA above double normal level was higher in tumors group than in non-tumors group(P<0.05).The sensitivity of two or more abnormalities in the combined detection of CEA

CA50 and CA19-9 was higher in tumors group than in non-tumors group(P<0.05).The sensitivity was 57.97% and 40.54% respectively.The specificity

accuracy

positive predictive value(PPV)and positive likelihood ratio(LR+)was 59.46%

58.74%

57.14% and 1.43 respectively.The sensitivity of three or more abnormalities in the combined detection of serum CEA

CA50

CA19-9 and CA125 was higher in tumors group than in non-tumors group(P<0.05).The sensitivity was 34.14% and 5.88% respectively.The specificity

accuracy

PPV and LR+ was 94.12%

61.33%

87.5% and 5.81 respectively.The aera under the ROC curves of CEA

CA50

CA19-9 and CA125 was 0.597

0.575

0.573 and 0.646 respectively.Conclusion:The diagnostic value of CEA

CA50

CA19-9 and CA125 in patients with obstructive jaundice from tumors is not obvious.CEA above double normal level

two or more abnormalities in the combined detection of CEA

CA50 and CA19-9 or three or more abnormalities in the combined detection of the four markers improve the probability of tumor.The specificity

PPV and LR+ of three or more abnormalities in the combined detection of CEA

CA50

CA19-9 and CA125 is higher than the ones of two or more abnormalities in the combined detection of the CEA

CA50 and CA19-9.

关键词

肿瘤标志物CEACA50CA19-9CA125梗阻性黄疸诊断

Keywords

tumor markerCEACA50CA19-9CA125obstructive jaundicediagnosis

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