Effects of pioglitazone on renal transforming growth factor β1,matrix metalloproteinase-9 and collagen type Ⅳ of diabetic rats

ZHANG Hong; HU Chang-jun; LU Wei-ping

doi:10.13406/j.cnki.cyxb.2011.07.022

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Effects of pioglitazone on renal transforming growth factor β1,matrix metalloproteinase-9 and collagen type Ⅳ of diabetic rats

更新时间：2024-01-17

- Effects of pioglitazone on renal transforming growth factor β1,matrix metalloproteinase-9 and collagen type Ⅳ of diabetic rats
- Journal of Chongqing Medical University Vol. 36, Issue 7, Pages: 826-828(2011)
- 作者机构：
  
  南京医科大学附属淮安第一医院内分泌科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.07.022
  CLC： R587.2
- Published：2011，
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[1]张红,胡长军,陆卫平.吡格列酮对糖尿病大鼠肾组织TGF-β1、MMP-9、Col-Ⅳ表达影响[J].重庆医科大学学报,2011,36(07):826-828.

ZHANG Hong, HU Chang-jun, LU Wei-ping. Effects of pioglitazone on renal transforming growth factor β1,matrix metalloproteinase-9 and collagen type Ⅳ of diabetic rats. [J]. Journal of Chongqing Medical University 36(7):826-828(2011)
[1]张红,胡长军,陆卫平.吡格列酮对糖尿病大鼠肾组织TGF-β1、MMP-9、Col-Ⅳ表达影响[J].重庆医科大学学报,2011,36(07):826-828. DOI： 10.13406/j.cnki.cyxb.2011.07.022.

ZHANG Hong, HU Chang-jun, LU Wei-ping. Effects of pioglitazone on renal transforming growth factor β1,matrix metalloproteinase-9 and collagen type Ⅳ of diabetic rats. [J]. Journal of Chongqing Medical University 36(7):826-828(2011) DOI： 10.13406/j.cnki.cyxb.2011.07.022.

摘要

目的:探讨吡格列酮对链脲佐菌素（Streptozotocin

STZ）诱导的糖尿病大鼠肾脏保护作用及机制。方法:实验用大鼠随机分为正常对照组（Normal control

NC）、糖尿病对照组（Diabetes mellitus control

DMC）、糖尿病吡格列酮治疗组（Diabetes treat-ed with pioglitazone

DP）。DP组给予吡格列酮20 mg/（kg.d）灌胃。8周后观察大鼠血糖、尿素氮（Blood urea nitrogen

BUN）、肾指数（Kidney index

KI）、尿微量白蛋白（Microalbuminuria

MAU）等生化指标

免疫组化法观察肾组织基质金属蛋白酶9（Matrixmetalloproteinase-9

MMP-9）、转化生长因子β1（Transforming growth factorβ1

TGF-β1）及Ⅳ型胶原（Collagen typeⅣ

Col-Ⅳ）的表达。结果:DMC组大鼠BUN、KI、MAU及肾组织TGF-β1、Col-Ⅳ的表达显著高于NC组（P<0.01）

而DP组BUN、KI、MAU及肾组织TGF-β1、Col-Ⅳ的表达较DMC组明显减低

差异具有显著性（P<0.01）。同时观察到DMC组MMP-9表达较NC组减低（P<0.01）

而DP组较DMC组显著升高（P<0.01）。结论:吡格列酮通过下调肾组织中TGF-β1、上调MMP-9表达

对糖尿病肾病（Diabetic nephropathy

DN）起保护作用。

Abstract

Objective:To study the effects of pioglitazone on diabetic nephropathy(DN)and related mechanisms.Methods:All rats were randomized into 3 groups:normal control(NC)

diabetes mellitus control(DMC)

and diabetes treated with pioglitazone(DP).After 8 weeks of treatment

blood glucose

kidney index(KI)

microalbuminuria(MAU)

blood urea nitrogen(BUN)

and the expression of transforming growth factor β1(TGF-β1)

matrix metalloproteinase-9(MMP-9)and collagen type Ⅳ(Col-Ⅳ)in kidney were observed by immunol histochemistry.Results:KI

MAU

BUN and the expression of TGF-β1 and Col-Ⅳ in DMC group were significantly higher than other two groups(P<0.01)

but the expression of MMP-9 in DMC group was significantly lower than other two groups(P<0.01).Conclusion:pioglitazone improves DN through down-regulating the expression of TGF-β1 and up-regulating MMP-9 in diabetic rats.

关键词

吡格列酮糖尿病肾病转化生长因子β1基质金属蛋白酶9Ⅳ型胶原

Keywords

pioglitazonediabetic nephropathytransforming growth factor β1matrix metalloproteinase-9collagen type Ⅳ

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