Study on preparation and in-vitro release of neostigmine bromide sustained-release tablets

LIAO Juan1; TAN Qun-you2; XIONG Hua-rong1; TAO Shao-lin2; ZHANG Jing-qin1

doi:10.13406/j.cnki.cyxb.2011.06.037

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Study on preparation and in-vitro release of neostigmine bromide sustained-release tablets

更新时间：2024-01-17

- Study on preparation and in-vitro release of neostigmine bromide sustained-release tablets
- Journal of Chongqing Medical University Vol. 36, Issue 6, Pages: 711-713(2011)
- 作者机构：
  
  1. 重庆医科大学药物高校工程研究中心和生物化学与分子药理学重点实验室
  2. 第三军医大学大坪医院野战外科研究所胸外科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.06.037
  CLC： R944
- Published：2011，
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[1]廖娟,谭群友,熊华蓉,陶绍林,张景勍.溴新斯的明1日2次缓释片的工艺优化及体外释放特性[J].重庆医科大学学报,2011,36(06):711-713.

LIAO Juan1, TAN Qun-you2, XIONG Hua-rong1, et al. Study on preparation and in-vitro release of neostigmine bromide sustained-release tablets. [J]. Journal of Chongqing Medical University 36(6):711-713(2011)
[1]廖娟,谭群友,熊华蓉,陶绍林,张景勍.溴新斯的明1日2次缓释片的工艺优化及体外释放特性[J].重庆医科大学学报,2011,36(06):711-713. DOI： 10.13406/j.cnki.cyxb.2011.06.037.

LIAO Juan1, TAN Qun-you2, XIONG Hua-rong1, et al. Study on preparation and in-vitro release of neostigmine bromide sustained-release tablets. [J]. Journal of Chongqing Medical University 36(6):711-713(2011) DOI： 10.13406/j.cnki.cyxb.2011.06.037.

摘要

目的:优化溴新斯的明1 d 2次缓释片的制备工艺并考察其体外释放特性。方法:采用亲水凝胶骨架与薄膜包衣控释技术制备溴新斯的明缓释片

并对处方进行体外累积释放度的考察。结果:所研制的缓释片能够持续释药12 h

释放规律符合一级释放方程。结论:溴新斯的明缓释片制备工艺合理

具有良好的缓释效果

符合设计要求。

Abstract

Objective:To optimize the preparation of neostigmine bromide sustained-release tablets and to study its in-vitro drug release property.Methods:Hydrophilic matrix tablets and film coating were used to prepare neostigmine bromide sustained-release tablets and the in-vitro accumulated release rate of the formula was studied.Results:The releasing of the sustained-release tablets prepared here lasts 12 hours and fits the first-order releasing equation.Conclusion:The neostigmine bromide sustained release tablets obtain good releasing and are consistent with specification.

关键词

溴新斯的明缓释片释放

Keywords

neostigmine bromidesustained-release tabletrelease

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