Expression of hypoxia inducible factor-1α in human gastric adenocarcinoma and it’s clinical significance

LIU Hai-yan1; SHEN Lei1; ZHANG Peng2; LI Jing-ping2; JI Liang2

doi:10.13406/j.cnki.cyxb.2011.06.032

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Expression of hypoxia inducible factor-1α in human gastric adenocarcinoma and it’s clinical significance

更新时间：2024-01-17

- Expression of hypoxia inducible factor-1α in human gastric adenocarcinoma and it’s clinical significance
- Journal of Chongqing Medical University Vol. 36, Issue 6, Pages: 657-659(2011)
- 作者机构：
  
  1. 齐齐哈尔医学院病理学系微形态实验中心
  2. 齐齐哈尔医学院基础医学院解剖教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.06.032
  CLC： R735.2
- Published：2011，
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[1]刘海燕,沈雷,张鹏,李静平,纪亮.缺氧诱导因子-1α在胃腺癌的表达及临床意义[J].重庆医科大学学报,2011,36(06):657-659.

LIU Hai-yan1, SHEN Lei1, ZHANG Peng2, et al. Expression of hypoxia inducible factor-1α in human gastric adenocarcinoma and it’s clinical significance. [J]. Journal of Chongqing Medical University 36(6):657-659(2011)
[1]刘海燕,沈雷,张鹏,李静平,纪亮.缺氧诱导因子-1α在胃腺癌的表达及临床意义[J].重庆医科大学学报,2011,36(06):657-659. DOI： 10.13406/j.cnki.cyxb.2011.06.032.

LIU Hai-yan1, SHEN Lei1, ZHANG Peng2, et al. Expression of hypoxia inducible factor-1α in human gastric adenocarcinoma and it’s clinical significance. [J]. Journal of Chongqing Medical University 36(6):657-659(2011) DOI： 10.13406/j.cnki.cyxb.2011.06.032.

摘要

目的:探讨缺氧诱导因子-1α（Hypoxia inducible factor-1

HIF-1α）表达与胃腺癌临床病理特征两者间的相关性。方法:应用免疫组织化学方法

检测63例胃腺癌组织、癌旁组织及正常组织中HIF-1α的表达。结果:HIF-1α蛋白在胃黏液腺癌组织的阳性率明显高于癌旁区组织、正常组织

差异具有显著性（P<0.05）;在胃黏液腺癌组织中

随着组织学病理分级的增加、临床分期的进展和淋巴结的转移

HIF-1α蛋白表达阳性率逐渐上升

差异具有统计学意义（P<0.05）。结论:HIF-1α表达与胃癌浸润、淋巴结转移和肿瘤大小有关

参与胃癌的发生和发展;HIF-1α可作为判断胃癌患者生物学行为及预后的指标之一

也为临床提供靶向治疗的方向。

Abstract

Objective:To observe the relativity between the expression of HIF-1α and the pathological clinical characteristics of gastric adenocarcinoma.Methods:To detect the expression of HIF-1α in the 63 normal gastric tissues and gastric adenocarcinoma using immunohistochemistry.Results:The positive rate of HIF-1α protein in gastric adenocarcinoma were apparently higher than the adjacent mucosa and normal gastric tissues(P<0.05).In gastric adenocarcinoma

along with the increase of histopathological grading

the advances of clinical staging

the metastasis of lymph node

the positive rate of HIF-1α protein increased gradually(P<0.05).Conclusion:The expression of HIF-1α were related to invasion of gastric cancer、the metastasis of lymph node、the size of the tumor.It may be taken as an index for evaluating carcinogenesis

progression

biological behaviors and prognosis of gastric carcinoma

and it may provide the way for clinical targeting treatment.

关键词

缺氧诱导因子-1α缺氧转移胃腺癌

Keywords

hypoxia inducible factor-1(HIF-1α)hypoxiametastasisgastric adenocarcinoma

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