Expression of DKK-1 and β-catenin in non-small cell lung cancer and their correlation

GUO Meng-gang; QIN Zhi-ming; LI Luo-chang

doi:10.13406/j.cnki.cyxb.2011.06.031

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Expression of DKK-1 and β-catenin in non-small cell lung cancer and their correlation

更新时间：2024-01-17

- Expression of DKK-1 and β-catenin in non-small cell lung cancer and their correlation
- Journal of Chongqing Medical University Vol. 36, Issue 6, Pages: 654-657(2011)
- 作者机构：
  
  重庆医科大学附属第一医院胸心外科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.06.031
  CLC： R734.2
- Published：2011，
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[1]郭孟刚,秦治明,李珞畅.DKK-1和β-catenin在非小细胞肺癌中的表达及其相关性[J].重庆医科大学学报,2011,36(06):654-657.

GUO Meng-gang, QIN Zhi-ming, LI Luo-chang. Expression of DKK-1 and β-catenin in non-small cell lung cancer and their correlation. [J]. Journal of Chongqing Medical University 36(6):654-657(2011)
[1]郭孟刚,秦治明,李珞畅.DKK-1和β-catenin在非小细胞肺癌中的表达及其相关性[J].重庆医科大学学报,2011,36(06):654-657. DOI： 10.13406/j.cnki.cyxb.2011.06.031.

GUO Meng-gang, QIN Zhi-ming, LI Luo-chang. Expression of DKK-1 and β-catenin in non-small cell lung cancer and their correlation. [J]. Journal of Chongqing Medical University 36(6):654-657(2011) DOI： 10.13406/j.cnki.cyxb.2011.06.031.

摘要

目的:探讨DKK-1（Dickkopf-1）和β-catenin在非小细胞肺癌（Non-small cell lung cancer

NSCLC）中的表达及其相关性。方法:采用免疫组化SP法检测60例NSCLC组织中DKK-1和β-catenin表达情况

并结合肺癌的临床病理特征进行分析。结果:在60例NSCLC病理组织中

DKK-1阳性表达率和β-catenin异常表达率分别为25.0%（15/60）和71.7%（43/60）。DKK-1的表达在肿瘤的分化程度、临床分期及淋巴结转移等方面有显著差异（P<0.05）;β-catenin的表达在肿瘤的分化程度方面差异有统计学意义（P<0.05）。在NSCLC中DKK-1和β-catenin的表达存在关联性（P<0.05）。结论:DKK-1的表达缺失可能在NSCLC的发生、发展中发挥一定的作用

它对β-catenin的影响可能是其发挥作用的机制之一。

Abstract

Objective:To investigate the expression of DKK-1 and β-catenin in non-small cell lung cancer and their correlation.Methods:The expression of DKK-1 and β-catenin were detected in pathological tissue sections from 60 patinets with non-small cell lung cancer by immunohistochemical SP method

and their clinical pathological features were analyzed statistically.Results:The positive expression rate of DKK-1 and the abnormal expression rate of β-catenin in non-small cell lung cancer tissue sections were 25.0%(15/60) and 71.7%(43/60)

respectively.The expression of DKK-1 was significantly associated with the degree of tumour differentiation

clinical stage and lymph node metastasis(P<0.05).The expression of β-catenin was significantly associated with the degree of tumour differentiation(P<0.05).There was association between the expression of DKK-1 and β-catenin in non-small cell lung cancer(P<0.05).Conclusion:The loss expression of DKK-1 may contribute to the progress of non-small cell lung cancer.Its effect on β-catenin may be one of the pathways for it to work.

关键词

DKK-1β-catenin非小细胞肺癌免疫组化

Keywords

dickkopf-1(DKK-1)β-cateninnon-small cell lung cancerimmunohistochemisty

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