Morphological changes in long-time chronic prostatitis rat models

ZHAO Xiu-juan; WANG Hong; XU Chen

doi:10.13406/j.cnki.cyxb.2011.06.021

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Morphological changes in long-time chronic prostatitis rat models

更新时间：2024-01-17

- Morphological changes in long-time chronic prostatitis rat models
- Journal of Chongqing Medical University Vol. 36, Issue 6, Pages: 696-698(2011)
- 作者机构：
  
  重庆医科大学生命科学研究院
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.06.021
  CLC： R697.33
- Published：2011，
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[1]赵秀娟,王红,徐晨.大鼠慢性前列腺炎模型长时程形态学研究[J].重庆医科大学学报,2011,36(06):696-698.

ZHAO Xiu-juan, WANG Hong, XU Chen. Morphological changes in long-time chronic prostatitis rat models. [J]. Journal of Chongqing Medical University 36(6):696-698(2011)
[1]赵秀娟,王红,徐晨.大鼠慢性前列腺炎模型长时程形态学研究[J].重庆医科大学学报,2011,36(06):696-698. DOI： 10.13406/j.cnki.cyxb.2011.06.021.

ZHAO Xiu-juan, WANG Hong, XU Chen. Morphological changes in long-time chronic prostatitis rat models. [J]. Journal of Chongqing Medical University 36(6):696-698(2011) DOI： 10.13406/j.cnki.cyxb.2011.06.021.

摘要

目的:探讨大鼠慢性前列腺炎（Chronic prostatitis

CP）模型长期造模后对前列腺形态学改变的影响。方法:选取SD大鼠

于0、30 d腹腔分别注射百白破疫苗

同时皮下多点注射20 g/L的大鼠前列腺蛋白提纯液及完全福氏佐剂（Freundg com-plete adjuvant

FCA）

第45、60、90、120天取材观察各组大鼠前列腺组织的形态学变化。结果:造模后不同时段前列腺组织学变化具有差异性。造模45 d后前列腺间质毛细血管周围出现淋巴细胞浸润

上皮细胞间隙增宽;60 d和90 d后

间质水肿明显

出现肥大细胞浸润;造模后120 d出现间质纤维化

腺腔扩张等病理变化。结论:长期造模的不同时段可反映CP不同的病理学变化过程

提示大鼠CP模型不同时间段可分别用于不同病理生理阶段的发病机理和临床治疗研究。

Abstract

Objective:To study the morphological changes of prostates in long-time prostatitis rat models at different stages.Methods:Male Sprague Dawley rats were intradermally immunized with pertussis-diphtheria-tetanus vaccine 0.5 ml combined with the saline extract of rat prostate glands(RPG) in concentrations of 20 mg/ml and Freundg complete adjuvant(FCA) i.P at the 0 and 30th day.Animals were sacrificed after 45 days

60 days

90 days and 120 days.Morphological changes of prostates were observed under light and electron microscope.Results:After 45 days

the lymphocytes were observed around the capillary vessels in intercellular substance of prostates;the intercellular spaced of epithelia were widened;interstitial edema and mast cell were apparent after 60 days and 90 days.The Interstitial fibrosis and dilatation of prostate lumens were remarkable after 120 days.Conclusion:The present study established all the pathological stages of chronic prostatitis and suggested that the chronic prostatitis models at different stages could be used for studying the mechanism of CPPS at different pathophysilogical stages and providing refrence for their clinical treatment.

关键词

自身免疫性前列腺炎动物模型

Keywords

autoimmune prostatitisanimal model

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