Diagnosis value of anti-p53 antibody in sera from patients with laryngeal carcinoma

YANG Xuan; ZHOU Jian-rong; FENG Ming-liang; ZHANG Yao-dong; XUE Lian

doi:10.13406/j.cnki.cyxb.2011.05.037

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Diagnosis value of anti-p53 antibody in sera from patients with laryngeal carcinoma

更新时间：2024-01-17

- Diagnosis value of anti-p53 antibody in sera from patients with laryngeal carcinoma
- Journal of Chongqing Medical University Vol. 36, Issue 5, Pages: 524-526(2011)
- 作者机构：
  
  重庆医科大学附属第一医院耳鼻咽喉科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.05.037
  CLC： R739.65
- Published：2011，
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[1]杨旋,周建荣,冯明亮,张耀东,薛莲.血清抗p53抗体在喉癌患者中的诊断意义[J].重庆医科大学学报,2011,36(05):524-526.

YANG Xuan, ZHOU Jian-rong, FENG Ming-liang, et al. Diagnosis value of anti-p53 antibody in sera from patients with laryngeal carcinoma. [J]. Journal of Chongqing Medical University 36(5):524-526(2011)
[1]杨旋,周建荣,冯明亮,张耀东,薛莲.血清抗p53抗体在喉癌患者中的诊断意义[J].重庆医科大学学报,2011,36(05):524-526. DOI： 10.13406/j.cnki.cyxb.2011.05.037.

YANG Xuan, ZHOU Jian-rong, FENG Ming-liang, et al. Diagnosis value of anti-p53 antibody in sera from patients with laryngeal carcinoma. [J]. Journal of Chongqing Medical University 36(5):524-526(2011) DOI： 10.13406/j.cnki.cyxb.2011.05.037.

摘要

目的:检测喉癌患者血清中抗p53抗体的阳性率

探讨抗p53抗体在喉癌中的诊断作用。方法:应用ELISA法检测4组共计99例血清样本中的抗p53抗体

即术前31例

术后第10天样本25例

术后第17天样本23例。术后10 d及17 d样本均来自于术前组术后患者。正常对照组20例。结果:在31例喉癌患者血清中14例高表达抗p53抗体

阳性率为45.2%;在手术治疗后10 d样本中4例高表达抗p53抗体

阳性率为16%;在手术后17 d及正常对照组中

无阳性表达。结论:抗p53抗体不仅可以成为一种新的喉癌标记分子

也可以作为判断喉癌患者预后的有效指标之一。

Abstract

Objective:To detect the anti-p53 antibody in sera from patients with laryngeal carcinoma and study the value of the antibody as a diagnosis factor in patients.Methods:The anti-p53 antibody of 99 sera samples were detected by enzyme-linked immunosorbent assay(ELISA)

including 31 samples before treatment

25 samples at 10 days after surgery

23 samples after 17 days

and 20 age-matched and sex-matched healthy volunteers.Results:14 of the 31(45.2%)

and 4 of the 25(16%)sera from patients were positive for anti-p53 antibody.Conclusion:Anti-p53 antibody may be not only suitable for diagnosis of laryngeal carcinoma

but also a prognostic indicator for patients with laryngeal carcinoma.

关键词

抗p53抗体喉癌酶联免疫吸附双抗体夹心法肿瘤标记分子

Keywords

anti-p53 antibodylaryngeal carcinomaELISAtumor marker

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Related Institution

Department of Otorhinolaryngology,The First Affiliated Hospital of Chongqing Medical University

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重庆医科大学第二临床学院耳鼻咽喉科

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