Observation on long time curative effect and safety of risperidone in treatment of schizophrenia

CAO Guo-xing; CAO Hua-qiong

doi:10.13406/j.cnki.cyxb.2011.05.036

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Observation on long time curative effect and safety of risperidone in treatment of schizophrenia

更新时间：2024-01-17

- Observation on long time curative effect and safety of risperidone in treatment of schizophrenia
- Journal of Chongqing Medical University Vol. 36, Issue 5, Pages: 621-623(2011)
- 作者机构：
  
  重庆市精神卫生中心
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.05.036
  CLC： R749.3
- Published：2011，
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[1]曹国兴,曹华琼.利培酮治疗精神分裂症长期疗效及安全性临床观察[J].重庆医科大学学报,2011,36(05):621-623.

CAO Guo-xing, CAO Hua-qiong. Observation on long time curative effect and safety of risperidone in treatment of schizophrenia. [J]. Journal of Chongqing Medical University 36(5):621-623(2011)
[1]曹国兴,曹华琼.利培酮治疗精神分裂症长期疗效及安全性临床观察[J].重庆医科大学学报,2011,36(05):621-623. DOI： 10.13406/j.cnki.cyxb.2011.05.036.

CAO Guo-xing, CAO Hua-qiong. Observation on long time curative effect and safety of risperidone in treatment of schizophrenia. [J]. Journal of Chongqing Medical University 36(5):621-623(2011) DOI： 10.13406/j.cnki.cyxb.2011.05.036.

摘要

目的:观察利培酮片对精神分裂症长期治疗的有效性、安全性及对社会功能的影响。方法:212例使用利培酮片剂治疗患者。平均剂量为（2.35±2.61）mg/d

疗程2年。用简明精神病量表（Briefpsychiatric rating scale

BPRS）评定疗效。用不良反应症状量表（Treatment emergent symptoms scale

TESS）评价药物副反应严重程度。用社会功能缺陷评定量表（Social disbil-ity screening schedule

SDSS）评定社会功能的影响程度。结果:利培酮具有良好疗效

有效率83.6%。SDSS量表评定:治疗前后比较有明显差异（P<0.01）。药物不良反应主要为锥体外系副反应（Extrapyramideal side effects

EPS）中静坐不能、抗胆碱能反应（视物模糊）、窦性心动过速

症状程度较轻;白细胞减少症1例

约10%患者体重增加（体重增加超过5%）与治疗前有显著性差异（P<0.01）。结论:利培酮长期治疗精神分裂症有效且安全

长期服用能够保持良好的社会功能。

Abstract

Objective:To observe the long time curative effect and safety of risperidone in treatment of schizophrenia.Methods:212 schizophrenia patients were treated with risperidone for two years

the average therapeutic dose was(2.35±2.61)mg/d.BPRS and SDSS were used to evaluste the therapeutic effect and TESS was used to evaluate the drug side effects.Results:Risperidone had saftisfactory effect on schizophrenia

83.6% of the patients was improved

compared with treatment before

there were significant improve on BPRS and SDSS(P<0.01).The main side effects were EPS、anti-AchE response and sinus tachycardia;a patient was diagnosed leukopenia

about 10% patients body weight gain(P<0.01).Conclusion:Risperidone can effectively and safely improve the symptoms of the patients with schizophrenia

patients can hold healthily social function during the long time curative.

关键词

利培酮精神分裂症长期疗效社会功能

Keywords

risperidoneschizophrenialong time curative effectsocial function

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重庆医科大学附属第一医院心理卫生中心

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