Objective:To discuss the feasibility of focused ultrasound treatment for cervical HPV infection.Methods:113 outpatients with cervical HPV infetion(HC2 test)in Chongqing Cancer Hospital from September 2007 to December 2009 were divided randomly into 3 groups.The control group(26 patients)did not receive any treatment;the observation group1(31 patients)received vaginal application of ɑ interferon for one month;the observation group 2(56 patients)received focused ultrasound once.Sexul life were prohibited in all the 3 groups during the study period.HPV was tested and the change compared three months later.Cervical cytology changes in the 3 groups were also compared three months later.Results:In the control group

observtion group 1 and observation group 2

the mean values of HPV before treatment were(396.10±19.73) μg/L

(281.82±16.38) μg/L

and(386.44±23.51) μg/L

respectively

while they were(292.11±17.78) μg/L

(175.24±13.81) μg/L

and(69.64±7.56) μg/L

respectively

after treatment.The self-control of before and after treatment in the three groups were significantly different(P <0.01).The value of HPV in observation group 2 decreased the most

followed by observation group 1 and control group

with the statistically significant difference among them(P <0.05).Cervical cytology changes were the most remarkable

the difference being statistically significant(P<0.05).The best effect was observed when the power of focused ultrasound was 800~950 J(P <0.05).Conclusion:It is feasible for focused ultrasound to treat cervical HPV infection without CIN

but its long-term safety still need long-term observation.The focused ultrasound’s effective power is 800~950 J.