Intrahepatic cholestasis of pregnancy diagnosis based on metabolic profiling of serum bile acid

TIAN Gang; ZHEN Qian-na; BAN Yan-na; TANG Xiu-fang; DING Min

doi:10.13406/j.cnki.cyxb.2011.05.027

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Intrahepatic cholestasis of pregnancy diagnosis based on metabolic profiling of serum bile acid

更新时间：2024-01-17

- Intrahepatic cholestasis of pregnancy diagnosis based on metabolic profiling of serum bile acid
- Journal of Chongqing Medical University Vol. 36, Issue 5, Pages: 586-588(2011)
- 作者机构：
  
  重庆医科大学检验系临床检验诊断学教育部重点实验室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.05.027
  CLC： R714.255
- Published：2011，
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[1]田刚,甄乾娜,班艳娜,唐秀芳,丁敏.血清胆汁酸代谢轮廓分析在妊娠肝内胆汁淤积症诊断中的应用[J].重庆医科大学学报,2011,36(05):586-588.

TIAN Gang, ZHEN Qian-na, BAN Yan-na, et al. Intrahepatic cholestasis of pregnancy diagnosis based on metabolic profiling of serum bile acid. [J]. Journal of Chongqing Medical University 36(5):586-588(2011)
[1]田刚,甄乾娜,班艳娜,唐秀芳,丁敏.血清胆汁酸代谢轮廓分析在妊娠肝内胆汁淤积症诊断中的应用[J].重庆医科大学学报,2011,36(05):586-588. DOI： 10.13406/j.cnki.cyxb.2011.05.027.

TIAN Gang, ZHEN Qian-na, BAN Yan-na, et al. Intrahepatic cholestasis of pregnancy diagnosis based on metabolic profiling of serum bile acid. [J]. Journal of Chongqing Medical University 36(5):586-588(2011) DOI： 10.13406/j.cnki.cyxb.2011.05.027.

摘要

目的:探讨血清胆汁酸代谢轮廓分析在妊娠肝内胆汁淤积症（Intrahepaticcholestasisofpregnancy

ICP）诊断中的作用。方法:应用柱前衍生HPLC-荧光检测法测定ICP患者

乙肝孕妇和正常孕妇（各11例）血清胆汁酸谱（5种游离型和4种甘氨结合型）

结合主成分分析法（Principal component analysis

PCA）和偏最小二乘判别分析法（Partial least-squares discriminantanalysis

PLS-DA）对血清胆汁酸谱进行分析。结果:血清胆汁酸代谢轮廓分析可区分ICP患者

乙肝孕妇和正常孕妇

其模型的正确诊断率和预测能力分别为97.0%和75.3%。结论:血清胆汁酸代谢轮廓分析有助于ICP的诊断和鉴别诊断。

Abstract

Objective:To study the feasibility of metabolic profiling of serum bile acid in intrahepatic cholestasis of pregnancy(ICP)diagnoses.Methods:High performance liquid chromatography(HPLC)with post column derivatisation and fluorescence detection were used to determinate 5 free and 4 glycine-conjugated serum bile acids in 11 healthy pregnant women

11 patients with ICP and 11 patients with hepatitis B.Data sets were analyzed by principal component analysis(PCA)and partial least-squares discriminant analysis(PLS-DA).Results:PCA and PLS-DA models showed a clear separation among ICP group

hepatitis B group and healthy controls

and PLS-DA model provided an accuracy of 97.0% for the diagnosis of diseases and a prediction power of 75.3%.Conclusion:Metabolic profiling analysis of serum bile acid is useful for diagnosis of ICP.

关键词

胆汁酸代谢轮廓分析血清妊娠肝内胆汁淤积症乙型肝炎

Keywords

bile acidmetabolic profiling analysisserumintrahepatic cholestasis of pregnancyhepatitis B

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Related Institution

Department of Obstetrics and Gynecology,The First Affiliated Hospital of Chongqing Medical University

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