Expression and significance of GATA6,ROR2 and STAT3 in bladder cell carcinoma

ZHANG Long-bo; GOU Xin; HE Wei-yang; ZHOU Qing-song

doi:10.13406/j.cnki.cyxb.2011.05.022

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Expression and significance of GATA6,ROR2 and STAT3 in bladder cell carcinoma

更新时间：2024-01-17

- Expression and significance of GATA6,ROR2 and STAT3 in bladder cell carcinoma
- Journal of Chongqing Medical University Vol. 36, Issue 5, Pages: 535-538(2011)
- 作者机构：
  
  重庆医科大学第一附属医院泌尿外科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.05.022
  CLC： R737.14
- Published：2011，
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[1]张龙波,苟欣,何卫阳,周青松.GATA6、ROR2和STAT3在膀胱移行细胞癌的表达及其意义[J].重庆医科大学学报,2011,36(05):535-538.

ZHANG Long-bo, GOU Xin, HE Wei-yang, et al. Expression and significance of GATA6,ROR2 and STAT3 in bladder cell carcinoma. [J]. Journal of Chongqing Medical University 36(5):535-538(2011)
[1]张龙波,苟欣,何卫阳,周青松.GATA6、ROR2和STAT3在膀胱移行细胞癌的表达及其意义[J].重庆医科大学学报,2011,36(05):535-538. DOI： 10.13406/j.cnki.cyxb.2011.05.022.

ZHANG Long-bo, GOU Xin, HE Wei-yang, et al. Expression and significance of GATA6,ROR2 and STAT3 in bladder cell carcinoma. [J]. Journal of Chongqing Medical University 36(5):535-538(2011) DOI： 10.13406/j.cnki.cyxb.2011.05.022.

摘要

目的:探讨核转录因子GATA6、发育调节激酶ROR2和信号转导因子STAT3在膀胱移行细胞癌中的表达及其临床意义。方法:采用免疫组织化学SP法检测72例膀胱移行细胞癌（Bladder transitional cell carcinoma

BTCC）组织中GATA6、ROR2和STAT3的表达

并将结果与病理分级、临床分期、肿瘤复发等临床病理资料进行统计学分析。结果:GATA6、ROR2和STAT3在BTCC的表达分别为:22.2%、61.1%、79.2%。不同病理分级和临床分期组间GATA6的表达差异无统计学意义（P>0.05）

但复发组与未复发组间其表达差异有统计学意义（P<0.05）;不同病理分级、临床分期

复发组与未复发组间ROR2的表达差异有统计学意义（P<0.05）;不同病理分级组间STAT3表达差异有统计学意义（P<0.05）

不同临床分期、复发与未复发组间差异无统计学意义（P>0.05）。（2）ROR2、STAT3在BTCC中的表达具有统计学相关性（rs=0.443

P<0.05）;GATA6在BTCC中的表达与ROR2、STAT3无统计学相关。结论:STAT3、ROR2和GATA6可能都参与了BTCC的进展;ROR2与STAT3可能存在共同的信号通路;检测GATA6、ROR2和STAT3可能对判断BTCC的进展和预后有一定价值。

Abstract

Objective:To investigate the expression and clinical significance of GATA6

ROR2

and STAT3 in bladder transitional cell carcinoma(BTCC).Methods:Expression of GATA6

ROR2

and STAT3 in 72 cases of BTCC detected by immunohistochemical SP method

and the results were analyzed statistically.Results:(1)The positive expression rate of GATA6 was significantly higher in recurrence group than in unrecurrence group(P<0.05)

while the expression of GATA6 did not increase with the ascended differentiation grade and pathology staging(P>0.05).(2)Positive expression rate of ROR2 in BTCC increased with the increase of differentiation grade and pathology staging(P<0.05)

and the expression rate of ROR2 was higher in recurrence group.(3)Positive rate of STAT3 in BTCC was significantly different among the different differentiation grade group(P<0.05)

and was of no significant difference in pathology staging group and recurrences group(P>0.05).(4)There was a highly significant positive correlation between the expression of ROR2 and STAT3(rs= 0.443

P<0.05)

but there was no significant positive correlation between ROR2 and GATA6

or between STAT3 and GATA6(P>0.05).Conclusion:GATA6

ROR2 and STAT3 might contribute to the development and recurrence of bladder transitional cell carcinoma.

关键词

膀胱移行细胞癌GATA6ROR2STAT3

Keywords

bladder transitional cell carcinomaGATA6ROR2STAT3

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