Objective:To study the performance of contrast-enhanced ultrasonography in renal artery stenosis.Methods:Animal models of renal artery stenosis were established by operation in the left kidney of New Zealand rabbits

and divided into four groups according to the degrees of renal artery stenosis based on CTA.The degrees of stenosis were <50%

50%~69%

70%~99% and 100% in GroupⅠ

GroupⅡ

GroupⅢ and GroupⅣ

respectively.Contrast-enhanced ultrasonography was performed in all rabbits.The AT

TTP

PBS and β on the time-intensity curves of left kidneys of the four groups were compared with those of the control group.Results:All the parameters of renal cortex and medulla in the four groups

except TTP of GroupⅡ

were statistically different from those of the control group when stenosis was more than 50%(P<0.05).However

the TTPs of GroupⅡ and GroupⅠ

and the βs of GroupⅢ and GroupⅡ had no significant differences.Conclusion:All the parameters of renal cortex and medulla in the four groups

except TTP in groupⅡ

are statistically different from those of the control group when renal artery stenosis is more than 50%.