Bioactivity study of lentinan on SGC-7901 cells growth in vitro

WANG Rong1; YI Min2; PAN Xian-ying1

doi:10.13406/j.cnki.cyxb.2011.05.004

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Bioactivity study of lentinan on SGC-7901 cells growth in vitro

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- Bioactivity study of lentinan on SGC-7901 cells growth in vitro
- Journal of Chongqing Medical University Vol. 36, Issue 5, Pages: 572-574(2011)
- 作者机构：
  
  1. 青海省肿瘤医院肿瘤放疗科
  2. 青海省肿瘤医院病理科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.05.004
  CLC： R285.5
- Published：2011，
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[1]王嵘,易敏,潘贤英.香菇多糖的体外抗肿瘤活性研究[J].重庆医科大学学报,2011,36(05):572-574.

WANG Rong1, YI Min2, PAN Xian-ying1. Bioactivity study of lentinan on SGC-7901 cells growth in vitro. [J]. Journal of Chongqing Medical University 36(5):572-574(2011)
[1]王嵘,易敏,潘贤英.香菇多糖的体外抗肿瘤活性研究[J].重庆医科大学学报,2011,36(05):572-574. DOI： 10.13406/j.cnki.cyxb.2011.05.004.

WANG Rong1, YI Min2, PAN Xian-ying1. Bioactivity study of lentinan on SGC-7901 cells growth in vitro. [J]. Journal of Chongqing Medical University 36(5):572-574(2011) DOI： 10.13406/j.cnki.cyxb.2011.05.004.

摘要

目的:研究香菇多糖体外抗肿瘤活性。方法:MTT法观察香菇多糖对胃癌细胞株SGC-7901增殖的影响

流式细胞术分析其对SGC-7901细胞周期的影响

Western blot法检测其对ERK1/2蛋白激酶磷酸化的作用。结果:香菇多糖能够显著抑制SGC-7901胃癌细胞的生长。香菇多糖作用于SGC-7901胃癌细胞后能够引起S期细胞周期阻滞

激活ERK1/2磷酸化。结论:香菇多糖具有体外抗肿瘤活性

其作用机制可能与诱导细胞周期阻滞和激活ERK1/2信号通路有关。

Abstract

Objective:To investigate inhibitory effects of lentinan on human tumor SGC-7901 cells growth in vitro.Methods:The potential effect of lentinan on the cell viability was examined using MTT assay.The cell cycle distribution of SGC-7901 cells treated with lentinan was analyzed by flow cytometry.Phosphorylation of ERK1/2 was detected by Western blot.Results:Lentinan strongly inhibited the SGC-7901 cells growth.Lentinan induced S phase cell cycle arrest and activated ERK1/2 phosphorylation in SGC-7901 cells.Conclusion:The anti-tumor activity of lentinan might be attributed partly to the induction of cell cycle arrest through ERK1/2 signal pathway.

关键词

香菇多糖肿瘤细胞周期ERK1/2

Keywords

lentinantumorcell cycleERK1/2

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