An analytical study of microvessel density in oral lichen planus

XIAO Zhi-li; et al

doi:10.13406/j.cnki.cyxb.2011.04.040

您当前的位置：

首页 >

文章列表页 >

An analytical study of microvessel density in oral lichen planus

更新时间：2024-01-17

- An analytical study of microvessel density in oral lichen planus
- Journal of Chongqing Medical University Vol. 36, Issue 4, Pages: 487-489(2011)
- 作者机构：
  
  重庆医科大学附属口腔医院牙周黏膜科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.04.040
  CLC： R781.5
- Published：2011，
扫描看全文
[1]萧智利,吴树洪,向学熔,黄姣.口腔扁平苔藓组织微血管密度的分析研究[J].重庆医科大学学报,2011,36(04):487-489.

XIAO Zhi-li, et al. An analytical study of microvessel density in oral lichen planus. [J]. Journal of Chongqing Medical University 36(4):487-489(2011)
[1]萧智利,吴树洪,向学熔,黄姣.口腔扁平苔藓组织微血管密度的分析研究[J].重庆医科大学学报,2011,36(04):487-489. DOI： 10.13406/j.cnki.cyxb.2011.04.040.

XIAO Zhi-li, et al. An analytical study of microvessel density in oral lichen planus. [J]. Journal of Chongqing Medical University 36(4):487-489(2011) DOI： 10.13406/j.cnki.cyxb.2011.04.040.

摘要

目的:测定正常颊黏膜组织、糜烂型及非糜烂型口腔扁平苔藓（Orallichen planus

OLP）组织和颊癌组织的微血管密度（Microvessel density

MVD）

观察其MVD的变化

为进一步探讨OLP的发病机理及治疗方法提供参考。方法:选择2008年12月至2010年3月在重庆医科大学附属口腔医院就诊的初诊患者共40例

包括10例糜烂型OLP

10例非糜烂型OLP和10例颊癌

收集10例颊部外伤创面组织作为正常人颊黏膜标本。组织切片采用CD34标记血管内皮细胞

S-P免疫组化染色

光学显微镜下测定MVD

用SPSS软件对数据进行统计学分析。结果:颊癌、糜烂型OLP、非糜烂型OLP、正常颊黏膜的MVD分别为:36.825 0±7.048 5、27.700 0±6.183 3、16.600 0±5.111 57、.350 0±1.472 9

经秩和检验分析

糜烂型OLP与正常对照组之间、颊癌与正常组织之间、颊癌与非糜烂型OLP之间的MVD差异有统计学意义（P<0.05）。结论:糜烂型OLP及颊癌较正常颊黏膜组织MVD明显增高;糜烂型与非糜烂型OLP的MVD差异无统计学意义;MVD与OLP组织的病变程度有明显相关性

可以考虑将MVD作为OLP治疗转归、癌变发展的评价指标。

Abstract

Objective:To detect the microvessel density(MVD) in tissue of normal buccal mucosa

erosive and non-erosive oral lichen planus and buccal cancer;to observe the microvessel density changes in order to further explore the pathogenesis of oral lichen planus and provide reference treatment.Methods:A total of 40 cases of newly diagnosed patients were selected from December 2008 to March 2010 in the affiliated hospital of stomatology

Chongqing medical university

including 10 cases of erosive OLP

10 cases of non-erosive OLP and 10 cases of buccal cancer

and 10 cases of buccal injury wound tissue collected as a normal buccal mucosa specimens.Tissue sections were performed by using vascular endothelial cell markers CD34

S-P immunohistochemistry.The microvessel density was measured under the optical microscope

with SPSS software for statistical analysis.Results:The MVD data for buccal cancer

erosive OLP

non-erosive OLP

and normal buccal mucosa were 36.825 0±7.048 5

27.700 0±6.183 3

16.600 0±5.111 5

and 7.350 0±1.472 9 respectively;by rank sum test

the difference of MVD between the erosive OLP and normal buccal mucosa

buccal cancer and normal buccal mucosa

buccal cancer and non-erosive OLP groups had statistical significance(P <0.05).Conclusion:The MVD of erosive OLP and buccal cancer is much higher than that of normal oral buccal mucosa;there’s no significant difference in MVD between the erosive and non-erosive OLP;the microvessel density and the severity of OLP tissue are significantly correlated

which could be considered as an evaluating index for the treatment and prognosis of OLP

as well as the development of cancer.

关键词

口腔扁平苔藓微血管密度CD34发病机理

Keywords

oral lichen planusmicrovessel densityCD34pathogenesis

references

Views

124

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Relationship between the expression of VEGF-C and microvessel and lymphatic microvessel density,and their role in the metastasis of gastric carcinoma

3D color power angiography in ovarian tumors and its relations hip to MVD, CD146 expression

Expression of SPARC in the squamous cervical carcinoma and its clinic significance

The study on the expression of Egr-1 and TNF-α in oral lichen planus

Expressions of HIF-1a，MMP-9 and MVD in renal carcinoma and their clinical significances

Related Author

时德

et al

PENG Qing-di

et al

ZHANG Long-yun

et al

DENG Ting

SHI Zhiyun

Related Institution

Department of General Surgery,the First Affiliated Hospital,Chongqing Medical University

重庆医科大学附属第一医院普外科

Department of Gynecology and Obstetrics,the First Affiliated Hospital,Chongqing Medical University

Department of Obstetrics and Gynecology,the First Affiliated Hospital,Chongqing Medical University

Department of Oral Medicine，School of Stomatology，Ningxia Medical University

⁰