Expression of Dicer protein in non-small cell lung cancer and its correlation with cancerous cell proliferation

ZHANG Shao-zhong; et al

doi:10.13406/j.cnki.cyxb.2011.04.037

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Expression of Dicer protein in non-small cell lung cancer and its correlation with cancerous cell proliferation

更新时间：2024-01-17

- Expression of Dicer protein in non-small cell lung cancer and its correlation with cancerous cell proliferation
- Journal of Chongqing Medical University Vol. 36, Issue 4, Pages: 466-469(2011)
- 作者机构：
  
  重庆医科大学附属第一医院胸心外科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.04.037
  CLC： R734.2
- Published：2011，
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[1]章少中,向小勇,陈力,葛明建.Dicer蛋白在非小细胞肺癌中表达及与癌细胞增殖的相互关系[J].重庆医科大学学报,2011,36(04):466-469.

ZHANG Shao-zhong, et al. Expression of Dicer protein in non-small cell lung cancer and its correlation with cancerous cell proliferation. [J]. Journal of Chongqing Medical University 36(4):466-469(2011)
[1]章少中,向小勇,陈力,葛明建.Dicer蛋白在非小细胞肺癌中表达及与癌细胞增殖的相互关系[J].重庆医科大学学报,2011,36(04):466-469. DOI： 10.13406/j.cnki.cyxb.2011.04.037.

ZHANG Shao-zhong, et al. Expression of Dicer protein in non-small cell lung cancer and its correlation with cancerous cell proliferation. [J]. Journal of Chongqing Medical University 36(4):466-469(2011) DOI： 10.13406/j.cnki.cyxb.2011.04.037.

摘要

目的:检测非小细胞肺癌（Non-small celllung cancer

NSCLC）组织中核酸内切酶Dicer、增殖细胞核抗原（Proliferating cell nuclear antigem

PCNA）蛋白的表达

探讨它们的相关性及临床意义。方法:应用免疫组织化学SP法

检测Dicer和PCNA在57例肺癌组织和16例癌旁正常肺组织表达情况

并结合肺癌的临床病理特征进行分析。结果:57例NSCLC Dicer蛋白失表达率50.9%

16例癌旁正常肺组织中为37.5%

二者差异无统计学意义（P>0.05）;Dicer蛋白在肺腺癌失表达率为66.7%

鳞癌中为37.0%

二者差异有统计学意义（P<0.05）;Dicer蛋白在高分化癌组（33.3%）失表达率低于低分化癌组（76.5%）

二者差异有统计学意义（P<0.05）;而与pTNM分期、淋巴结转移以及年龄、性别无关（P>0.05）;NSCLC癌组织中Dicer高表达和低表达的PCNA平均指数分别为（37.61±20.31）%、（48.32±25.34）%（P>0.05）。结论:Dicer蛋白失表达可能参与肺腺癌的发生发展过程

影响肺肿瘤细胞的分化方向

没有直接影响PCNA蛋白表达。

Abstract

Objective:To investigate the expression and significance of Dicer

PCNA protein in patients with non-small cell lung cancer.Methods:The expressions of Dicer protein and PCNA protein and the clinico-pathologic features of lung cancer in 57 cases of lung cancer and 16 cases of normal lung tissue were analyzed statistically by immunohistochemical SP method.Results:The loss of expression of Dicer protein in 57 cases of lung carcinoma was 50.9%

while in 16 cases of normal lung tissues the loss was 37.5%(P>0.05).The loss of expression of Dicer protein in lung adenocarcinoma was 66.7%

while the loss was 37.0% in squamous carcinoma

which was statistically significant(P<0.05)between the two pathological types.The loss of expression of Dicer protein in high differentiation carcinoma(33.3%)was lower than in low differentiation carcinoma(76.5%)

which was statistically significant(P<0.05)between high and low differentiation cancers.However

no correlation was found between pTNM stages

lymph node metastasis

age and gender(P>0.05).The mean index of proliferating cell nuclear antigen(PCNA)in low and high level expression of Dicer were(48.32±25.34)% and(37.61±20.31)% respectively(P>0.05).Conclusion:The loss of expression of Dicer protein may take part in the onset and process of lung adenocarcinoma;it influences the direction of differentiation of the lung carcinoma cell and is not directly linked to the expression of PCNA protein.

关键词

Dicer癌细胞增殖非小细胞肺癌免疫组化

Keywords

dicer proteincancer cell proliferationnon-small cell lung cancerimmunohistochemistry

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