Expression and significance of FEZ1 in papillary thyroid carcinoma

YUAN Zhi-qing; et al

doi:10.13406/j.cnki.cyxb.2011.04.035

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Expression and significance of FEZ1 in papillary thyroid carcinoma

更新时间：2024-01-17

- Expression and significance of FEZ1 in papillary thyroid carcinoma
- Journal of Chongqing Medical University Vol. 36, Issue 4, Pages: 437-440(2011)
- 作者机构：
  
  1. 郑州大学第一附属医院内分泌科
  2. 河南省漯河市第三人民医院骨科
  3. 新乡医学院病理学教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.04.035
  CLC： R736.1
- Published：2011，
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[1]原志庆,陈晓磊,李娜,贺国洋,王霞,杨慧林,郑丽丽.FEZ1基因在甲状腺乳头状癌中的表达及其意义[J].重庆医科大学学报,2011,36(04):437-440.

YUAN Zhi-qing, et al. Expression and significance of FEZ1 in papillary thyroid carcinoma. [J]. Journal of Chongqing Medical University 36(4):437-440(2011)
[1]原志庆,陈晓磊,李娜,贺国洋,王霞,杨慧林,郑丽丽.FEZ1基因在甲状腺乳头状癌中的表达及其意义[J].重庆医科大学学报,2011,36(04):437-440. DOI： 10.13406/j.cnki.cyxb.2011.04.035.

YUAN Zhi-qing, et al. Expression and significance of FEZ1 in papillary thyroid carcinoma. [J]. Journal of Chongqing Medical University 36(4):437-440(2011) DOI： 10.13406/j.cnki.cyxb.2011.04.035.

摘要

目的:探讨肿瘤抑制基因FEZ1在甲状腺乳头状癌（Papillary thyroid cancer

PTC）中的表达及其与PTC临床病理特征之间的关系。方法:采用原位杂交（Insitu hybridizationI

SH）技术和免疫组织化学（Immunohistoc hemistryI

HC）检测30例正常甲状腺组织、30例PTC组织和30例PTC组织中FEZ1 mRNA和蛋白的表达情况

并分析其与PTC临床病理参数的关系。结果:FEZ1 mRNA和蛋白在正常甲状腺组织中的阳性表达率均显著高于甲状腺腺瘤（P均<0.05）和PTC组织（P均<0.05）;FEZ1 mRNA和蛋白在Ⅰ、Ⅱ期PTC组织中的阳性表达率均显著高于Ⅲ、Ⅳ期PTC组织中的阳性表达率（P均<0.05）;无淋巴结转移组中的FEZ1 mRNA和蛋白阳性表达率亦均显著高于伴淋巴结转移组（P均<0.05）。PTC中FEZ1 mRNA和蛋白的表达呈正相关关系（P<0.05）。结论:FEZ1基因的表达缺失或下调与PTC的发生与演进存在密切关系。

Abstract

Objective:To investigate expression of tumor suppressor gene FEZ1 and whether there is a correlation between FEZ1 expression and clinicopathological features of papillary thyroid carcinoma.Methods:The expression of FEZ1 mRNA and protein in 30 cases of normal thyroid and 30 cases of adenomas and 30 cases of papillary thyroid carcinoma were detected by in situ hubridyzation(ISH) and immuno-histochemistry(IHC)methods.Results:The positive expression rate of FEZ1 mRNA and protein in normal thyroid were significantly higher than that in adenomas(P<0.05)and papillary thyroid cancer(P<0.05).The positive expression rate of FEZ1 mRNA and protein in clinical pathology stage ofⅠandⅡwas significantly higher than that in clinical pathology stage of Ⅲ and Ⅳ(P<0.05).The positive expression rate of FEZ1 mRNA and protein in lymphotic metastasis negative group were significantly higher than that in lymphotic metastasis positive group(P<0.05).Conclusion:The non-expression or low expression of FEZ1 gene may be relation with the occurrence and progression of papillary thyroid cancer.

关键词

甲状腺乳头状癌FEZ1免疫组织化学原位杂交甲状腺腺瘤

Keywords

papillary thyroid cancerFEZ1immuno-histochemistryin situ hubridyzationthyroid adenoma

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