Effect of focused ultrasound exposure patterns on bovine liver damages n vitro

MIAO Ji-dong; et al

doi:10.13406/j.cnki.cyxb.2011.04.034

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Effect of focused ultrasound exposure patterns on bovine liver damages n vitro

更新时间：2024-01-17

- Effect of focused ultrasound exposure patterns on bovine liver damages n vitro
- Journal of Chongqing Medical University Vol. 36, Issue 4, Pages: 394-397(2011)
- 作者机构：
  
  1. 四川省自贡市第四人民医院肿瘤科
  2. 重庆医科大学生物医学工程系医学超声工程研究所
  3. 重庆医科大学附属第一医院肝胆外科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.04.034
  CLC： R735.7
- Published：2011，
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[1]缪继东,伍烽,王济明.聚焦超声辐照方式对离体牛肝损伤的影响[J].重庆医科大学学报,2011,36(04):394-397.

MIAO Ji-dong, et al. Effect of focused ultrasound exposure patterns on bovine liver damages n vitro. [J]. Journal of Chongqing Medical University 36(4):394-397(2011)
[1]缪继东,伍烽,王济明.聚焦超声辐照方式对离体牛肝损伤的影响[J].重庆医科大学学报,2011,36(04):394-397. DOI： 10.13406/j.cnki.cyxb.2011.04.034.

MIAO Ji-dong, et al. Effect of focused ultrasound exposure patterns on bovine liver damages n vitro. [J]. Journal of Chongqing Medical University 36(4):394-397(2011) DOI： 10.13406/j.cnki.cyxb.2011.04.034.

摘要

目的:比较高强度聚焦超声（Highintensity focused ultrasound

HIFU）双向、单向两种辐照模式损伤离体肝脏的情况。方法:使用聚焦超声设备（超声换能器频率为1.6 MHz

声功率为300 W

声强为12 000 W/cm2）对厚度8 cm和10 cm离体牛肝进行连续辐照。双向辐照模式采用2个聚焦超声换能器固定于钳状手柄上

2个换能器呈对向排列;单向辐照模式采用单一聚焦超声换能器

相对侧安装一金属反射板。在超声频率测量靶区牛肝凝固性坏死的形状和特征

记录辐照后靶区温度变化。结果:在双向辐照模式下

HIFU能造成整个牛肝的贯通性凝固性坏死

凝固性形状类似长方体

凝固性坏死体积大于单向模式;双向辐照模式辐照后靶区牛肝温度高于单向辐照模式。结论:HIFU双向辐照模式能造成预定靶区牛肝的贯通性凝固性坏死

效果优于单向辐照模式。

Abstract

Objective:To compare the destructive characteristics of the bovine liver in vitro by double or single high intensity focused ultrasound exposure patterns.Methods:Two HIFU instruments(frequency of 1.6 MHz

acoustic power of 300 W

in situ intensity of 12 000 W/cm2)were used to ablate in vitro bovine liver ranging from 8 cm and 10 cm.In double exposure mode

two focused ultrasound transducers were fixed on the handle;the directions of focused ultrasound beams were opposite.In the single exposure mode

one focused ultrasound transducer was fixed on one handle

and a metal reflector was fixed on the other handle.The characteristics of coagulation necrosis and temperature change in treated bovine liver were observed.Results:In the double exposure mode

HIFU instrument induced complete coagulation necrosis of predetermined bovine liver targets

and the coagulation necrosis shape was similar to circular cylinder.However

under the same exposure energy and exposure time

the target area coagulation necrosis volume and the temperature were higher than those in the single side exposure mode.Conclusion:Working in double side exposure mode

HIFU can induce complete coagulation necrosis of predetermined bovine liver targets

and the effect surpasses the single side exposure mode.

关键词

高强度聚焦超声肝切除出血

Keywords

high intensity focused ultrasoundhepatectomybleeding

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Related Author

MIAO Ji-dong

et al

胡晓东

赵纯亮

伍烽

Qiu Jianguo

Tang Wei

Shi Zhengrong

Related Institution

Department of Biomedical Engineering,Institute of Ultrasound Engineering in Medicine,Chongqing Medical University

Department of Hepatobiliary Surgery,The First Affiliated Hospital of Chongqing Medical University

重庆医科大学医学超声工程研究所

Department of Urology, the Second College of Clinical Medicine , Chongqing Medical University

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