Expression and significance of plasma BDNF in patients with schizophrenia

ZENG Yan; et al

doi:10.13406/j.cnki.cyxb.2011.04.033

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Expression and significance of plasma BDNF in patients with schizophrenia

更新时间：2024-01-17

- Expression and significance of plasma BDNF in patients with schizophrenia
- Journal of Chongqing Medical University Vol. 36, Issue 4, Pages: 476-478(2011)
- 作者机构：
  
  重庆医科大学附属第一医院心理卫生中心
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.04.033
  CLC： R749.3
- Published：2011，
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[1]曾妍,况利,甘窈,陈建梅,艾明,王我,苟芯源,王俊,徐小明.精神分裂症患者血清BDNF的表达及相关研究[J].重庆医科大学学报,2011,36(04):476-478.

ZENG Yan, et al. Expression and significance of plasma BDNF in patients with schizophrenia. [J]. Journal of Chongqing Medical University 36(4):476-478(2011)
[1]曾妍,况利,甘窈,陈建梅,艾明,王我,苟芯源,王俊,徐小明.精神分裂症患者血清BDNF的表达及相关研究[J].重庆医科大学学报,2011,36(04):476-478. DOI： 10.13406/j.cnki.cyxb.2011.04.033.

ZENG Yan, et al. Expression and significance of plasma BDNF in patients with schizophrenia. [J]. Journal of Chongqing Medical University 36(4):476-478(2011) DOI： 10.13406/j.cnki.cyxb.2011.04.033.

摘要

目的:探讨精神分裂症患者血清脑源性神经营养因子（Brainderived neurotrophic factor

BDNF）的水平和特点。方法:收集精神分裂症患者44名和正常对照者45名

使用阳性和阴性症状量表（The positive and negative syndrome scale

PANSS）对患者疾病的严重程度进行评分

使用酶联免疫吸附法检测血清BDNF水平

用SPSS18.0软件对数据进行统计分析。结果:患者血清BDNF水平明显低于正常对照人群（P<0.01）;患者血清BDNF水平与其病程和疾病严重程度无明显相关。结论:BDNF可能成为精神分裂症的生物学标志物之一。

Abstract

Objective:To investigate the characteristics of plasma brain-derived neurotrophic factor(BDNF)levels in patients with schizophrenia and the possibility of BDNF as the biological marker of schizophrenia.Methods:44 patients with schizophrenia and 45 matched normal controls were enrolled.Assessment was performed with Positive and Negative Syndrome Scale(PANSS)

and serum BDNF levels were detected by ELISA.All data were analyzed by SPSS18.0.Results:①Serum BDNF levels in patients with schizophrenia were significantly decreased compared with those in normal controls(P<0.01);②No significant correlation was found between serum BDNF levels in patients and their severities of schizophrenia.Conclusion:BNDF may be a candidate biological marker of schizophrenia.

关键词

精神分裂症血清脑源性神经营养因子

Keywords

schizophreniaserumbrain-derived neurotrophic factor

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Related Institution

Department of Neurology，The First Affiliated Hospital of Chongqing Medical University

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Department of Neurology,The First Affiliated Hospital of Chongqing Medical University

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重庆医科大学第二临床学院内分泌研究室

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