High intensity focused ultrasound in SYP of neonatal rat with hypoxic-ischemic brain damage

HU Weng-jing; et al

doi:10.13406/j.cnki.cyxb.2011.04.030

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High intensity focused ultrasound in SYP of neonatal rat with hypoxic-ischemic brain damage

更新时间：2024-01-17

- High intensity focused ultrasound in SYP of neonatal rat with hypoxic-ischemic brain damage
- Journal of Chongqing Medical University Vol. 36, Issue 4, Pages: 408-411(2011)
- 作者机构：
  
  1. 重庆医科大学附属儿童医院神经康复科
  2. 国家超声重点实验室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.04.030
  CLC： R722.1
- Published：2011，
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[1]胡文静,周江堡,廖丛,李东,司维,王志彪.高强度聚焦超声对新生鼠缺血缺氧性脑损伤SYP的影响[J].重庆医科大学学报,2011,36(04):408-411.

HU Weng-jing, et al. High intensity focused ultrasound in SYP of neonatal rat with hypoxic-ischemic brain damage. [J]. Journal of Chongqing Medical University 36(4):408-411(2011)
[1]胡文静,周江堡,廖丛,李东,司维,王志彪.高强度聚焦超声对新生鼠缺血缺氧性脑损伤SYP的影响[J].重庆医科大学学报,2011,36(04):408-411. DOI： 10.13406/j.cnki.cyxb.2011.04.030.

HU Weng-jing, et al. High intensity focused ultrasound in SYP of neonatal rat with hypoxic-ischemic brain damage. [J]. Journal of Chongqing Medical University 36(4):408-411(2011) DOI： 10.13406/j.cnki.cyxb.2011.04.030.

摘要

目的:研究国家超声重点实验室研制的高强度聚焦超声（Highintensity focused ultrasound

HIFU）对新生鼠缺血缺氧性脑损伤（Hypoxic-ischemic brain damage

HIBD）的突触素（Synaptophysin

SYP）的影响。方法:选取7 d龄SD大鼠192只

随机分成4组:（1）假手术组（n=48

A）;（2）模型组（n=48

B）;（3）电针组（n=48

C）;（4）超声组（n=48

D）。每组又分为治疗1、2、3周3个亚组

每亚组8只

免疫组织化学染色和RT-PCR方法检测脑组织中海马区域SYP表达水平。结果:各时间点电针组和超声组SYP表达明显高于假手术组和模型组（P<0.05）。结论:HIFU穴位治疗可以上调SYP的表达

对HIBD后的脑组织具有神经保护效应。其机制可能是聚焦超声穴位治疗时其物理效应能起到类似针灸时经络传导增加缺血缺氧性脑损伤大鼠脑区突触的作用。

Abstract

Objective:To study the treatment of high intensity focused ultrasound(HIFU) in synaptophysin(SYP)of neonatal rats with hypoxic-ischemic brain damage(HIBD).Methods:One hundred and ninety-two 7-day-old SD rats were randomly divided into four groups:1 sham group(n=48

2 HIBD model group(n=48

3 acupuncture group(n=48

4 high intensity focused ultrasound group(n=48

every group respectively divided into 1w

3w sub-groups(n=8).The expressions of synaptophysin(SYP)in Hippocampus were examined with immunohistochemical staining and RT-PCR.Results:In high intensity focused ultrasound group and acupuncture group

SYP expression levels were significantly higher than those in sham group and HIBD model group(P<0.05)

which had distinct differences compared with the HIBD model group.The expressions of SYP in high intensity focused ultrasound group had no difference compared with acupuncture group.Conclusion:High-intensity focused ultrasound therapy can enhance the expression of SYP level

which has neuroprotective function.Its possible mechanism is that when HIFU is focused on the point

it can play a similar role like acupuncture which can increase the synaptic of HIBD.

关键词

新生大鼠缺血缺氧性脑损伤高强度聚焦超声电针突触素

Keywords

neonatal rathypoxic-ischemichigh-intensity focused ultrasoundacupuncturesynaptophysin(SYP)

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