Association between serum complement C3 and metabolic syndrome and its components in women with polycystic ovary syndrome

LUO Cheng; et al

doi:10.13406/j.cnki.cyxb.2011.04.029

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Association between serum complement C3 and metabolic syndrome and its components in women with polycystic ovary syndrome

更新时间：2024-01-17

- Association between serum complement C3 and metabolic syndrome and its components in women with polycystic ovary syndrome
- Journal of Chongqing Medical University Vol. 36, Issue 4, Pages: 433-436(2011)
- 作者机构：
  
  重庆医科大学附属第一医院内分泌科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.04.029
  CLC： R711.75
- Published：2011，
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[1]罗成,李启富,杨淑敏,宋颖,田波,刘洲君,王邦琼,张素华.血清补体C3与多囊卵巢综合征患者代谢综合征及其组分的相关性研究[J].重庆医科大学学报,2011,36(04):433-436.

LUO Cheng, et al. Association between serum complement C3 and metabolic syndrome and its components in women with polycystic ovary syndrome. [J]. Journal of Chongqing Medical University 36(4):433-436(2011)
[1]罗成,李启富,杨淑敏,宋颖,田波,刘洲君,王邦琼,张素华.血清补体C3与多囊卵巢综合征患者代谢综合征及其组分的相关性研究[J].重庆医科大学学报,2011,36(04):433-436. DOI： 10.13406/j.cnki.cyxb.2011.04.029.

LUO Cheng, et al. Association between serum complement C3 and metabolic syndrome and its components in women with polycystic ovary syndrome. [J]. Journal of Chongqing Medical University 36(4):433-436(2011) DOI： 10.13406/j.cnki.cyxb.2011.04.029.

摘要

目的:研究血清补体C3（Serum complementC3

C3）与多囊卵巢综合征（Polycystic ovary syndrome

PCOS）患者代谢综合征（Metabolic syndrome

MS）及其组分的相关性。方法:纳入91例PCOS患者及115例年龄匹配的女性健康对照组。收集人体测量指标及实验室检查数据

评估C3与其他参数间的关系。结果:PCOS组与对照组相比

C3值升高[（1.39±0.33）g/L、（1.10±0.22）g/L

P<0.05];在PCOS人群中

存在MS任意一组分或MS患者C3水平明显高于无MS者

且随着MS成份数目增多

C3水平逐渐升高（P<0.05）。相关性分析表明

PCOS患者C3水平与体重指数、腰围、收缩压、舒张压、空腹血浆葡萄糖、餐后2 h血浆葡萄糖、空腹胰岛素、甘油三脂、总胆固醇、低密度脂蛋白胆固醇、胰岛素抵抗指数呈正相关（r=0.65、0.63、0.36、0.29、0.39、0.49、0.56、0.58、0.40、0.32、0.58

P<0.05）

而与M值、高密度脂蛋白胆固醇呈负相关（r=-0.65-、0.36

P<0.05）。多元线性回归分析显示在PCOS患者中

腰围（β=0.31

P<0.05）和总胆固醇（β=0.23

P<0.05）是C3有意义的影响因素。二项Logistic回归分析提示C3水平增高的PCOS患者发生MS的风险明显增加（P<0.05）。结论:C3是PCOS人群中MS的危险因子。

Abstract

Objective:To investigate the association between serum complement C3(C3)and metabolic syndrome(MS)and its components in women with polycystic ovary syndrome(PCOS).Methods:91 women with PCOS and 115 age-matched normal women were enrolled in this study.Anthropometric measurements and biochemical parameters were evaluated to find the relationship between C3 and other parameters.Results:The concentration of C3 was significantly higher in women with PCOS compared with control subjects(1.39± 0.33) g/L vs(1.10±0.22) g/L

P<0.05);it was also higher in subjects with MS or any components of MS in PCOS;and the C3 level rose gradually along with the increase of the number of MS features(P<0.05).Correlation analyses indicated that the C3 was associated positively with BMI

waistline

systolic blood pressure

diastolic blood pressure

fasting plasma glucose

2-h plasma glucose

fasting insulin

triglyceride

total cholesterol

LDL-c and Homa-IR(r=0.65

0.63

0.36

0.29

0.39

0.49

0.56

0.58

0.40

0.32

0.58

P<0.05)

While negatively with M value and HDL-c(r=-0.65

-0.36

P<0.05).Multiple linear regression showed WC and TG(β=0.31

P<0.05)

TG(β=0.23

P<0.05)were significant influential factors for C3.Binary logistic regression analysis showed that subjects in PCOS group were more likely to get MS when C3 increase(P<0.05).Conclusion:High concentration of C3 is a risk factor for MS in women with PCOS.

关键词

血清补体C3多囊卵巢综合征代谢综合征

Keywords

serum complement C3polycystic ovary syndromemetabolic syndrome

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