The correlation between CA19-9 and type 2 diabetes mellitus

XIA li; et al

doi:10.13406/j.cnki.cyxb.2011.04.016

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The correlation between CA19-9 and type 2 diabetes mellitus

更新时间：2024-01-17

- The correlation between CA19-9 and type 2 diabetes mellitus
- Journal of Chongqing Medical University Vol. 36, Issue 4, Pages: 474-475(2011)
- 作者机构：
  
  重庆医科大学附属第一医院老年科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.04.016
  CLC： R587.1
- Published：2011，
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[1]夏丽,肖谦,向娟.血清CA19-9与2型糖尿病患者血糖控制的相关性研究[J].重庆医科大学学报,2011,36(04):474-475.

XIA li, et al. The correlation between CA19-9 and type 2 diabetes mellitus. [J]. Journal of Chongqing Medical University 36(4):474-475(2011)
[1]夏丽,肖谦,向娟.血清CA19-9与2型糖尿病患者血糖控制的相关性研究[J].重庆医科大学学报,2011,36(04):474-475. DOI： 10.13406/j.cnki.cyxb.2011.04.016.

XIA li, et al. The correlation between CA19-9 and type 2 diabetes mellitus. [J]. Journal of Chongqing Medical University 36(4):474-475(2011) DOI： 10.13406/j.cnki.cyxb.2011.04.016.

摘要

目的:探讨2型糖尿病（2diabetes mellitus

T2DM）患者血糖控制水平与血清CA19-9的相关性。方法:化学发光法测定T2DM患者（A组

120例）及非糖尿病患者（B组

108例）的血清CA19-9水平。2组均排除其它可能导致CA19-9水平升高的常见疾病。按糖化血红蛋白水平将A组分为血糖控制组（A1组

58例

HbA1c≤7.0%）和非控制组（A2组

62例

HbA1c>7.0%）。统计软件SPSS17.0对各组进行组间对比分析

对可能影响CA19-9水平与T2DM的相关因素进行单因素相关分析及多元逐步回归分析。结果:组间对比分析结果显示

A组血清CA19-9水平显著高于B组（P<0.01）;A1组与A2组比

A1组血清CA19-9水平低于A2组（P<0.01）。单因素相关分析显示

血清CA19-9水平与糖化血红蛋白（P<0.05）、糖尿病病程（P<0.05）存在相关性。多元逐步回归分析发现血清CA19-9水平与患者糖化血红蛋白呈线性相关。结论:血清CA19-9升高与T2DM存在相关性

可作为血糖控制水平的参考指标之一。

Abstract

Objective:To investigate the correlation between serum CA19-9 levels and type 2 diabetes mellitus(T2DM)

and to analyze the relationship between blood glucose(BG)

T2DM correlation factors and CA19-9 levels.Methods:This was a retrospective observation.120 inpatients with T2DM(group A)were recruited into this study

and 108 non-T2DM inpatient(group B)were used as controls.Routine tests were examined in both of two groups to exclude other diseases

which might be responsible for increased CA19-9.Patients with T2DM were classified as two subgroups according to HbA1c level.A1 subgroup was considered as BG controlled group(HbA1c≤7.0%)

and A2 subgroup was considered as BG uncontrolled group(HbA1c>7.0%).CA19-9 concentration was measured with the electro-chemiluminescence immunoassay.Data were analyzed by SPSS17.0 software packet

and independent samples t-test was used for simple correlation analysis and stepwise linear regression analysis.Results:The independent samples t-test analysis showed the CA19-9 level of A was higher than that of B(P<0.01);that of A1 was lower than that of A2(P<0.01).Correlation analysis showed positive correlation between HbA1c

duration of T2DM and CA19-9.Stepwise regression analysis showed a positive linear correlation between HbA1c and CA19-9.Conclusion:The positive rate of CA19-9 is correlated with T2DM.There is a significant linear correlation between CA19-9 and HbA1c.This study suggests that CA19-9 is one of reference marker for BG control.

关键词

CA19-92型糖尿病糖化血红蛋白

Keywords

CA19-9T2DMHbA1c

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