Adherence with dual antiplatelet therapy and its influence on clinical outcomes in patients after undergoing percutaneous coronary stenting for 1 year

ZHANG Ya-mei; et al

doi:10.13406/j.cnki.cyxb.2011.04.015

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Adherence with dual antiplatelet therapy and its influence on clinical outcomes in patients after undergoing percutaneous coronary stenting for 1 year

更新时间：2024-01-17

- Adherence with dual antiplatelet therapy and its influence on clinical outcomes in patients after undergoing percutaneous coronary stenting for 1 year
- Journal of Chongqing Medical University Vol. 36, Issue 4, Pages: 503-506(2011)
- 作者机构：
  
  重庆医科大学附属第二医院老年病科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.04.015
  CLC： R541.4
- Published：2011，
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[1]张亚梅,陈庆伟.PCI术后1年患者双联抗血小板药物治疗依从性随访研究[J].重庆医科大学学报,2011,36(04):503-506.

ZHANG Ya-mei, et al. Adherence with dual antiplatelet therapy and its influence on clinical outcomes in patients after undergoing percutaneous coronary stenting for 1 year. [J]. Journal of Chongqing Medical University 36(4):503-506(2011)
[1]张亚梅,陈庆伟.PCI术后1年患者双联抗血小板药物治疗依从性随访研究[J].重庆医科大学学报,2011,36(04):503-506. DOI： 10.13406/j.cnki.cyxb.2011.04.015.

ZHANG Ya-mei, et al. Adherence with dual antiplatelet therapy and its influence on clinical outcomes in patients after undergoing percutaneous coronary stenting for 1 year. [J]. Journal of Chongqing Medical University 36(4):503-506(2011) DOI： 10.13406/j.cnki.cyxb.2011.04.015.

摘要

目的:探讨经皮冠状动脉介入治疗（Percutaneous coronary intervention

PCI）术后1年患者双联抗血小板药物治疗依从性状况及其对临床预后的影响。方法:选取2007年2月至2010年2月连续3年在重庆医科大学附属第二医院老年病科接受PCI并植入支架的547例冠心病（Coronary heart disease

CHD）患者

进行随访

评估患者术后1年服用抗血小板药物的依从性及其影响因素、停药原因;并初步探讨依从性对临床预后的影响。所得数据均采用SPSS17.0统计软件进行分析处理。结果:PCI术后1年内患者服用双联抗血小板药物完全依从的患者有315例（63%）

82例（16.4%）患者仅服用阿司匹林

71例（14.2%）仅服用氯吡格雷

32例（6.4%）双联抗血小板药物均停服;患者依从性与年龄（P=0.024）、文化程度（P=0.034）、医疗付费方式（P=0.000）及合并疾病数（P=0.004）相关

而与性别（P=0.406）、病变血管支数（P=0.538）无显著相关性;PCI术后双联抗血小板药物依从的患者出院后1年主要心脏不良事件（Major adverse cardiac events

MACE）发生率及靶血管重建率较非依从的患者低（P=0.007;P=0.024）。结论:PCI术后患者双联抗血小板药物治疗存在非依从问题及严重后果

患者年龄、文化程度、医疗付费方式及合并疾病数可影响患者服药依从性

依从性差导致患者PCI术后累计MACE及靶血管重建发生率增高。

Abstract

Objective:To investigate the adherence with dual antiplatelet therapy and its influence on clinical outcomes in patients after undergoing percutaneous coronary stenting for 1 year.Methods:The follow-up was performed in 547 patients undergoing coronary stenting in our department from February 2007 to February 2010

including the adherence of antiplatelet therapy and its correlating factors and the influence on clinical outcomes.The statistical package for social science(SPSS)17.0 was used for analyze all the statistics.Results:At follow-up

315 patients(63%)maintained adherence to the dual antiplatelet therapy

82 patients(16.4%) and 71 patients(14.2%)respectively took aspirin and clopidogrel alone.There were 32 patiens(6.4%)who completely discontinued all antiplatelet agents.The age(P=0.024)

educational level(P=0.034)

medical payment(P=0.000)and the comorbidities(P=0.004) have effect on medication adherence.During 1-year follow-up

the accumulated incidence of MACE and target vessel revascularization(TVR)in aderent group was lower than that of non-adherent group(P=0.007

P=0.024

respectively).Conclusion:In clinical practices

the adherence with antiplatelet therapy in patients undergoing coronary stent implantation was poor.The age

educational level

medical payment and the comorbidities have effect on medication adherence

and non-adherence to antiplatelet therapy is considered as importent risk factors for MACE and TVR.

关键词

经皮冠状动脉介入治疗抗血小板服药依从性预后

Keywords

percutaneous coronary interventionantiplatelet therapyadherenceprognosis

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