The clinical analysis of patients with thrombotic microangiopathy by continuous renal replacement therapy

CAI Ying; et al

doi:10.13406/j.cnki.cyxb.2011.04.014

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The clinical analysis of patients with thrombotic microangiopathy by continuous renal replacement therapy

更新时间：2024-01-17

- The clinical analysis of patients with thrombotic microangiopathy by continuous renal replacement therapy
- Journal of Chongqing Medical University Vol. 36, Issue 4, Pages: 490-493(2011)
- 作者机构：
  
  重庆医科大学附属第二医院肾内科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.04.014
  CLC： R543
- Published：2011，
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[1]蔡莹,唐琳,钟玲,冯利平,雷建蓉,胡廷海,廖晓辉.连续性肾脏替代治疗对血栓性微血管病治疗的临床分析[J].重庆医科大学学报,2011,36(04):490-493.

CAI Ying, et al. The clinical analysis of patients with thrombotic microangiopathy by continuous renal replacement therapy. [J]. Journal of Chongqing Medical University 36(4):490-493(2011)
[1]蔡莹,唐琳,钟玲,冯利平,雷建蓉,胡廷海,廖晓辉.连续性肾脏替代治疗对血栓性微血管病治疗的临床分析[J].重庆医科大学学报,2011,36(04):490-493. DOI： 10.13406/j.cnki.cyxb.2011.04.014.

CAI Ying, et al. The clinical analysis of patients with thrombotic microangiopathy by continuous renal replacement therapy. [J]. Journal of Chongqing Medical University 36(4):490-493(2011) DOI： 10.13406/j.cnki.cyxb.2011.04.014.

摘要

目的:观察连续性肾脏替代治疗（Continuous renal replacement therapy

CRRT）对血栓性微血管病（Thrombotic microan-giopathy

TMA）的治疗效果。方法:对我院10例经CRRT治疗的TMA患者的临床资料进行回顾性分析。结果:10例患者存活7例

存活率为70%

存活者中3例治愈

4例好转

好转者中2例继续治疗基础疾病

2例慢性肾衰竭摆脱透析。治疗后存活患者实验室指标:Hb（107.1±26.8）g/L、Plt（162.6±73.0）×109个/L、血肌酐（Serum creatinine

Scr）（136.1±51.2）μmol/L、总胆红素（Total bilirubin

TBIL）（30.2±44.2）μmol/L、间接胆红素（Indirect bilirubinI

BIL）（10.1±4.2）μmol/L、乳酸脱氢酶（Lactate dehy-drogenase

LDH）（211.6±102.9）U/L较治疗前Hb（61.6±13.7）g/L、Plt（41.1±16.7）×109个/L、Scr（421.4±93.3）μmol/L、TBIL（140.6±149.2）μmol/LI、BIL（34.7±21.4）μmol/L、LDH（647.7±422.5）U/L明显好转（P<0.05）。结论:CRRT在临床上治疗TMA有效

有效降低死亡率。

Abstract

Objective:To observe the treatment effect on thrombotic microangiopathy(TMA) by continuous renal replacement therapy(CRRT).Methods:Retrospectively analyze the clinical data of 10 patients with thrombotic microangiopathy admitted to our hospital and treated by CRRT.Results:Seven cases of 10 patients survived

the survival rate was 70%.Among the survived patients

3 patients were cured

4 cases were improved.Among the 4 survived cases

2 patients continue to the treatment for the underlying disease

2 patients with chronic renal failure were independed on hemodialysis after treatment.Laboratory tests of survival patients after treatment

including Hb(88.6±16.4) g/L

Plt(162.6±73.0)×109/L

serum creatinine(Scr)(136.1±51.1) μmol/L

total bilirubin(TBIL)(30.2±44.2)μmol/L、indirect bilirubin(IBIL)(17.3±11.8) μmol/L

and lactate dehydrogenase(LDH)(254.0±150.1) U/L were significantly better than those before treatment(Hb(61.6±13.7) g/L

Plt(41.1±16.7)×109/L

Scr(421.4±93.3) μmol / L

TBIL(140.6±149.2) μmol/L

IBIL(95.3±104.6) μmol/L

LDH(647.7±150.1)U/L)(P<0.05).Conclusion:CRRT can be effective on the treatment of TMA and reduce mortality.

关键词

连续性肾脏替代治疗血栓性微血管病临床分析

Keywords

continuous renal replacement therapythrombotic microangiopathyclinical studies

references

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