Objective:To study the toxic effects of cinnamon acid germanium in the experiment.Methods:Acute toxicity tests were adopted to calculate the median lethal dose and the maximum tolerated dose of the drugs;and to check mice’s biochemical indicators.The various organs were drawn out after mice were killed by pharmacological test

and the spleen and thymus weight indexes were calculated;The organs’ pathological changes were observed under ordinary microscope after HE staining.Results:LD50 could not be calculated

which showed cinnamon acid germanium had little toxicity.The maximum tolerated dose of mice could reached 1.2 g/kg weight.Mice’s biochemical indicators had no statistical significance.The spleen and thymus weight indexes in treated group have no statistical significance

This indicated the drugs’ immune influence in mice had no significant effect in the short term.Compared with normal saline group and cyclopho-sphamide group

the organs in treated group showed no obvious pathological changes under ordinary microscope.Conclusion:The experiment shows that cinnamon acid germanium compounds have no apparent toxic effects.This can provide some experimental evidence for further anti-tumor activity researches and applications.