Effect of intensities of electroacupuncture on C-reactive protein and interleukin-6 in adipose tissues from high fat diet-induced obese rats

LIU Zu-li; et al

doi:10.13406/j.cnki.cyxb.2011.04.004

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Effect of intensities of electroacupuncture on C-reactive protein and interleukin-6 in adipose tissues from high fat diet-induced obese rats

更新时间：2024-01-17

- Effect of intensities of electroacupuncture on C-reactive protein and interleukin-6 in adipose tissues from high fat diet-induced obese rats
- Journal of Chongqing Medical University Vol. 36, Issue 4, Pages: 429-432(2011)
- 作者机构：
  
  1. 重庆医科大学中医药学院针灸推拿科
  2. 重庆医科大学科研处基金科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.04.004
  CLC： R245.97
- Published：2011，
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[1]刘祖丽,唐成林,余敏,侯懿烜,郜婕,刘仁建.电针刺激对肥胖大鼠脂肪组织C反应蛋白、白细胞介素-6表达的影响[J].重庆医科大学学报,2011,36(04):429-432.

LIU Zu-li, et al. Effect of intensities of electroacupuncture on C-reactive protein and interleukin-6 in adipose tissues from high fat diet-induced obese rats. [J]. Journal of Chongqing Medical University 36(4):429-432(2011)
[1]刘祖丽,唐成林,余敏,侯懿烜,郜婕,刘仁建.电针刺激对肥胖大鼠脂肪组织C反应蛋白、白细胞介素-6表达的影响[J].重庆医科大学学报,2011,36(04):429-432. DOI： 10.13406/j.cnki.cyxb.2011.04.004.

LIU Zu-li, et al. Effect of intensities of electroacupuncture on C-reactive protein and interleukin-6 in adipose tissues from high fat diet-induced obese rats. [J]. Journal of Chongqing Medical University 36(4):429-432(2011) DOI： 10.13406/j.cnki.cyxb.2011.04.004.

摘要

目的:观察不同强度电针刺激对单纯性肥胖大鼠脂肪组织C反应蛋白（C-reactive protein

CRP）、白细胞介素-6（In-terleukin-6

IL-6）蛋白表达的影响。方法:选用SD雄性大鼠

随机分为对照组、模型组、2 V电针组、1 V电针组

对照组用普通鼠饲料喂养

其余各组均用高脂饲料喂养。针刺大鼠"足三里"和"三阴交"穴

采用不同强度电针治疗14 d后

比较治疗前后各组大鼠体重指数（Lees’指数）

用酶联免疫吸附法检测肥胖大鼠附睾脂肪组织CRP的含量

用蛋白质印迹技术检测肥胖大鼠附睾脂肪组织IL-6蛋白表达。结果:2电针组肥胖大鼠Lees’指数较模型组显著降低（P<0.01）

电针组脂肪组织中CRP的含量及IL-6的表达较模型组显著降低（P<0.01）

2 V电针组与1 V电针组比较

也有显著差异（P<0.01

P<0.05）。结论:电针能有效减轻肥胖大鼠体重

降低肥胖大鼠脂肪组织CRP的含量和IL-6的表达

改善肥胖大鼠机体的炎症反应状态

且2 V电针组效果优于1 V电针组。

Abstract

Objective:To investigate the effect of intensities of electroacupuncture on C-reactive protein(CRP)and interleukin-6(IL-6) in adipose from high fat diet-induced simply obese rats.Methods:Male SD rats were randomly divided into control group(CG

n=10)

model group with high fat diet only(MG

n=10)

electroacupuncture groups with high fat diet fed rats stimulated by either 2 V(2 V EA

n=10)or 1v of electroacupuncture(1 V EA

n=10).Electroacupuncture(10 Hz

2 V EA:2 V

1 V EA:1 V)was applied to acupuncture points"Zu san li" and "San yin jiao"for 15min everyday and for 14 days.Lee’s index in each group were detected.The contents of CRP in epididymis adipose tissue were detected by ELISA.The expression of IL-6 in epididymis adipose tissue was detected by Western blotting.Results:Lee’s index and expression of CRP

IL-6 from two EA groups were significantly decreased compared with the model group(P<0.01)

and obvious change was observed between the two EA groups(P<0.01

P<0.05).Conclusion:Electroacupuncture can reduce obese rats’weight

decrease the expressions of CRP and IL-6 in epididymis adipose tissue and improve inflammatory state in obese rats.Moreover

2 V EA group exhibits a better effect compared with 1 V EA group.

关键词

电针单纯性肥胖脂肪组织炎症

Keywords

electroacupuncturesimple obesityadipose tissueinflammation

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