Protective effect of probucol on the kidney of aging rats induced by D-galactose

LI Yao; et al

doi:10.13406/j.cnki.cyxb.2011.02.041

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Protective effect of probucol on the kidney of aging rats induced by D-galactose

更新时间：2024-01-17

- Protective effect of probucol on the kidney of aging rats induced by D-galactose
- Journal of Chongqing Medical University Vol. 36, Issue 2, Pages: 171-173(2011)
- 作者机构：
  
  1. 辽宁医学院基础学院生理学教研室
  2. 辽宁医学院附属第一医院肾内科
  3. 锦州市中心医院内分泌内科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.02.041
  CLC： R965
- Published：2011，
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[1]李垚,冯欣,王雪鹰.普罗布考对D-半乳糖致衰老大鼠肾脏的保护作用研究[J].重庆医科大学学报,2011,36(02):171-173.

LI Yao, et al. Protective effect of probucol on the kidney of aging rats induced by D-galactose. [J]. Journal of Chongqing Medical University 36(2):171-173(2011)
[1]李垚,冯欣,王雪鹰.普罗布考对D-半乳糖致衰老大鼠肾脏的保护作用研究[J].重庆医科大学学报,2011,36(02):171-173. DOI： 10.13406/j.cnki.cyxb.2011.02.041.

LI Yao, et al. Protective effect of probucol on the kidney of aging rats induced by D-galactose. [J]. Journal of Chongqing Medical University 36(2):171-173(2011) DOI： 10.13406/j.cnki.cyxb.2011.02.041.

摘要

目的:本实验主要研究抗氧化剂普罗布考对D-半乳糖致衰老大鼠肾脏的保护作用及可能机制。方法:将36只大鼠随机分为3组

正常对照组12只;衰老模型组12只;普罗布考治疗组12只。大鼠每日腹腔注射D-半乳糖

按每只小鼠100 mg/kg的剂量给药

连续42 d

形成亚急性衰老模型。做组织学检查

观察肾组织病理改变

测定肾组织超氧化物歧化酶（Superoxidedismutase

SOD）、谷胱甘肽过氧化物酶（Glutathione peroxidase

GSH-Px）的活性及丙二醛（Malondialdehyde

MDA）含量。结果:组织学检查发现模型组出现了肾小球体积增大

分布稀疏

不同程度的局灶节段性肾小球硬化

肾小管的管腔扩大

灶状小管萎缩

间质纤维化

而给药组肾组织改变与模型组相比有所减轻。模型组肾组织SOD和GSH-Px的活性明显降低

给药组比模型组有所增高。模型组MDA的含量明显增高

给药组比模型组降低（P<0.05）。结论:普罗布考能有效地抑制脂质过氧化产物MDA的产生

并提高抗氧化酶SOD、GSH-Px的活性

抑制氧化损伤过程

从而起到延缓肾脏衰老的作用。

Abstract

Objective: To evaluate protective effects and possible mechanism of probucol on the kidney of aging rats induced by D-galactose.Methods:36 rats were divided randomly into 3 groups : negative control group(12 rats)

aging group(12 rats)

and probucol treatment group(12 rats).The sub-acute aging model rats were made by injecting D-gal into abdomen continuously(100 mg/kg

42 d).The morphological changes were observed.The activities of superoxide dismutase(SOD) and GSH-Px and the concentration of malondialdehyde(MDA) in the kidney were examined.Results:There were obvious glomerular dilatation

focal glomeru-lonephritis

tubular dilatation

part of the tubular atrophy and tubulointerstitial fibrosis in model groups.These changes were remarkably relieved in probucol treatment group.The activities of SOD and GSH-Px in model group were decreased

and the concentration of MDA was increased.In comparison

the activities of SOD and GSH-Px in treatment group were significantly increased

and the concentration of MDA was decreased(P<0.05).Conclusion:Probucol can decrease the level of MDA and increase the activities of SOD and GSH-Px

and suppress oxidative stress injury

so it has anti-aging effects.

关键词

普罗布考衰老超氧化歧化酶谷胱甘肽过氧化物酶丙二醛

Keywords

probucolagingsuperoxide dismutaseglutathione peroxidasemalondialdehyde

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