Expressions of maspin and mmp-2 in non-small cell lung cancer and their clinical significance

LU Jun; et al

doi:10.13406/j.cnki.cyxb.2011.02.034

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Expressions of maspin and mmp-2 in non-small cell lung cancer and their clinical significance

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- Expressions of maspin and mmp-2 in non-small cell lung cancer and their clinical significance
- Journal of Chongqing Medical University Vol. 36, Issue 2, Pages: 177-180(2011)
- 作者机构：
  
  1. 湖北省宜昌市第二人民医院胸外科
  2. 武汉市二医院胸外科
  3. 华中科技大学同济医学院附属协和医院胸外科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.02.034
  CLC： R734.2
- Published：2011，
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[1]卢军,汪毓君,王家顺.Maspin和mmp-2在非小细胞肺癌中的表达及其临床意义[J].重庆医科大学学报,2011,36(02):177-180.

LU Jun, et al. Expressions of maspin and mmp-2 in non-small cell lung cancer and their clinical significance. [J]. Journal of Chongqing Medical University 36(2):177-180(2011)
[1]卢军,汪毓君,王家顺.Maspin和mmp-2在非小细胞肺癌中的表达及其临床意义[J].重庆医科大学学报,2011,36(02):177-180. DOI： 10.13406/j.cnki.cyxb.2011.02.034.

LU Jun, et al. Expressions of maspin and mmp-2 in non-small cell lung cancer and their clinical significance. [J]. Journal of Chongqing Medical University 36(2):177-180(2011) DOI： 10.13406/j.cnki.cyxb.2011.02.034.

摘要

目的:研究肿瘤抑制基因蛋白maspin（Mammary-serpin）和基质金属蛋白酶-2（Matrix metalloproteinase-2

mmp-2）在非小细胞肺癌（Non-small cell lungcancer

NSCLC）中的表达

探讨maspin和mmp-2的相关性及其与临床病理特征的关系。方法:选择手术切除的65例NSCLC患者的标本

肺部良性病变组织及正常肺组织标本各8例

采用免疫组化SP法检测NSCLC组织、肺部良性病变及正常肺组织中maspin和mmp-2的表达情况。结果:maspin蛋白在正常肺组织和肺部良性病变组织中高表达

阳性率分别为100%（8/8）和87.5%（7/8）

在NSCLC中其阳性率显著降低

为15.4%（10/65）。mmp-2在正常肺组织和肺部良性病变组织中不表达或低表达

阳性率分别为12.5%（1/8）和37.5%（3/8）

而其在NSCLC中则显著高表达

阳性率为73.3%。maspin蛋白在NSCLC的表达与淋巴结转移相关

mmp-2在NSCLC的表达与淋巴结转移和TNM分期相关

两者与性别、年龄、肿瘤大小、组织学类型和组织分化程度不相关。结论:maspin蛋白在NSCLC中表达下调

mmp-2在NSCLC中过度表达

并且maspin蛋白与mmp-2的表达成负相关（rs=-0.54

P=0.018）。它们在肺癌浸润转移中起重要作用

可作为反映肺癌病理生物学行为的有效指标。

Abstract

Objective:To investigate the expressions of maspin and the matrix metalloproteinase-2 and correlation between maspin and mmp-2 protein in NSCLC and their clinical significance.Methods: Immunohistochemical SP method was used to detect the expressions of maspin and mmp-2 in 65 NSCLC tssues

8 tissues of benign disease of lung

and 8 normal lung tissues.Results:Maspin protein in normal lung tissues and benign lesions in the lungs were of high expression:the positive rates were 100%(8/8) and 87.5%(7/8)respectively.The positive rate of NSCLC showed a significant reduction which was 15.4%(10/65).mmp-2 in normal lung tissues and benign lesions of the lungs did not express or showed low-expression: the positive rates were 12.5%(1/8) and 37.5%(3/8)respectively

and its expression in NSCLC was significantly higher

which is 73.3%.Maspin protein expression in NSCLC had a correlation with lymph node metastasis

and mmp-2 expression in NSCLC had a correlation with lymph node metastasis and TNM staging.Both maspin protein and mmp-2 did not show correlation between the two genders

age

tumor size

or histological type.Conclusion:The expression of maspin protein in NSCLC is down-regulated and mmp-2 shows an over-expression in NSCLC.The expression of Maspin protein and mmp-2 has a negative correlation(rs=-0.54

P=0.018).They play an important role in invasion and metastasis in lung cancer.They can be an effective indicator of biological behavior which can reflect lung cancer pathology.

关键词

非小细胞肺癌免疫组织化学maspin基质金属蛋白酶-2

Keywords

NSCLCimmunohistochemicalmaspinmmp-2

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