Clinical analysis of antiepileptic drug hypersensitivity syndrome on 20 children

TANG Chun-hui; et al

doi:10.13406/j.cnki.cyxb.2011.02.027

您当前的位置：

首页 >

文章列表页 >

Clinical analysis of antiepileptic drug hypersensitivity syndrome on 20 children

更新时间：2024-01-17

- Clinical analysis of antiepileptic drug hypersensitivity syndrome on 20 children
- Journal of Chongqing Medical University Vol. 36, Issue 2, Pages: 228-229(2011)
- 作者机构：
  
  云南省第一人民医院儿科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.02.027
  CLC： R742.1
- Published：2011，
扫描看全文
[1]汤春辉,田云粉.儿童抗癫痫药高敏综合症20例临床分析[J].重庆医科大学学报,2011,36(02):228-229.

TANG Chun-hui, et al. Clinical analysis of antiepileptic drug hypersensitivity syndrome on 20 children. [J]. Journal of Chongqing Medical University 36(2):228-229(2011)
[1]汤春辉,田云粉.儿童抗癫痫药高敏综合症20例临床分析[J].重庆医科大学学报,2011,36(02):228-229. DOI： 10.13406/j.cnki.cyxb.2011.02.027.

TANG Chun-hui, et al. Clinical analysis of antiepileptic drug hypersensitivity syndrome on 20 children. [J]. Journal of Chongqing Medical University 36(2):228-229(2011) DOI： 10.13406/j.cnki.cyxb.2011.02.027.

摘要

目的:总结我院20例诊断为抗癫痫药高敏综合征（Antiepileptic drug hypersensitivitysyndrome

AHS）患儿的临床特征、治疗方法及所用抗癫痫药

提高对本病的认识

为临床救治工作提供参考。方法:回顾性分析我院2000年1月至2010年4月诊断为AHS患儿的临床资料。结果:20例患儿中其中19例服用的是含芳香环抗癫痫药物

仅1例服用非芳香族抗癫痫药

所有患儿均有皮疹和发热。结论:AHS的临床表现各异

极易引起误诊

对儿童危害更大

故有必要充分认识AHS。芳香族抗癫痫药由于均含有苯环结构

易致AHS

且同类药存在高频率的交叉反应。

Abstract

Objective: The clinical features

therapeutic method and antiepileptics of antiepileptic drug hypersensitivity syndrome(AHS) on 20 children were analyzed

it’s good for recognition and remedy of this kind of disease.Methods: The retrospective analysis was carried out on the clinical data of the children treated in our hospital from Jan 2000 to Apr 2010 who were diagnosed as AHS.Results: 19 of 20 children were treated with aromatic antiepileptic drugs and the other 1 was treated with non-aromatic antiepileptic drugs.All children suffered skin rash and fever.Conclusion: The clinical situation of AHS was different and it was easy to cause diagnostic errors.So it was necessary to recognize AHS fully to prevent further harm to the suffered children.The benzene ring in the molecular structure of aromatic antiepileptic drug was believed to be a cause of AHS

and altofrequent cross reaction was observed in congener drugs.

关键词

儿童抗癫痫药高敏综合征

Keywords

childrenantiepileptic drughypersensitivity syndrome

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Epidemiological and clinical characteristics of human rhinovirus infection in children hospitalized due to lower respiratory tract infections in Yinchuan，China

Genetic testing of children with suspected thalassemia in Chongqing area of China: an analysis of 28 287 cases

Advances in clinical management of thyroid cancer in children and adolescents

Cluster analysis on types of family management for children with malignant tumor

Comparison of the application of rigid bronchoscope and soft bronchoscope in children's bronchial foreign bodies

Related Author

Hei Zhiping

Guo Jianhui

Ji Kai

Yan Yan

Wang Chunli

Li Fang

Sun Yuning

Wang Ming

Related Institution

Department of Biochemistry and Molecular Biology,School of Basic Medicine,Ningxia Medical University

Department of Clinical Medicine,Ningxia Medical University

Department of Respiratory and Critical Care Medicine,General Hospital of Ningxia Medical University

Department of Clinical Molecular Medicine of Children’s Hospital of Chongqing Medical University， National Clinical Research Center for Child Health and Disorders，Ministry of Education Key Laboratory of Child Development and Disorders，Chongqing Key Laboratory of Pediatrics

Department of Endocrinology， Guangdong Provincial People’s Hospital，Guangdong Academy of Medical;Sciences

⁰