Determination of encapsulation efficiency of capsaicin in compound capsaicin nanoemulsion

JIANG Zhan; et al

doi:10.13406/j.cnki.cyxb.2011.02.009

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Determination of encapsulation efficiency of capsaicin in compound capsaicin nanoemulsion

更新时间：2024-01-17

- Determination of encapsulation efficiency of capsaicin in compound capsaicin nanoemulsion
- Journal of Chongqing Medical University Vol. 36, Issue 2, Pages: 195-197(2011)
- 作者机构：
  
  重庆医科大学药学院天然药物化学教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.02.009
  CLC： R283
- Published：2011，
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[1]姜展,刘新,张桂平,郭虎.复方辣椒碱纳米乳中辣椒碱包封率的测定方法研究[J].重庆医科大学学报,2011,36(02):195-197.

JIANG Zhan, et al. Determination of encapsulation efficiency of capsaicin in compound capsaicin nanoemulsion. [J]. Journal of Chongqing Medical University 36(2):195-197(2011)
[1]姜展,刘新,张桂平,郭虎.复方辣椒碱纳米乳中辣椒碱包封率的测定方法研究[J].重庆医科大学学报,2011,36(02):195-197. DOI： 10.13406/j.cnki.cyxb.2011.02.009.

JIANG Zhan, et al. Determination of encapsulation efficiency of capsaicin in compound capsaicin nanoemulsion. [J]. Journal of Chongqing Medical University 36(2):195-197(2011) DOI： 10.13406/j.cnki.cyxb.2011.02.009.

摘要

目的:建立复方辣椒碱（Capsaicin）纳米乳中主药辣椒碱包封率的测定方法。方法:应用葡聚糖凝胶G50微型柱分离获取纳米乳

再采用HPLC测定纳米乳中的辣椒碱含量

换算包封率。结果:葡聚糖凝胶微柱获取纳米乳的平均回收率为97.98%（n=9）

纳米乳中辣椒碱含量测定方法显示

在浓度5～80μg/ml浓度范围内

辣椒碱与其峰面积的线性关系良好（r=0.999 4）

平均回收率为98.17%（n=9）

RSD=1.69%。3批样品中辣椒碱的包封率分别为83.17%、87.74%和85.26%。结论:所建方法能有效地消除其他成分对测定的干扰

可用于复方纳米乳制剂中辣椒碱包封率的测定。

Abstract

Objective:To establish a method to determine the encapsulation efficiency of capsaicin in compound capsaicin nanoemulsion.Methods: Dextran Gel G50 mini-column was used to separate the nanoemulsion.The concentration of capsaicin in the nanoemulsion was detected by HPLC and converted into encapsulation efficiency.Results: The recovery of the Dextran Gel G50 mini-column was 97.98%(n=9).The linear range of capcaisin in the determination method was 5~80 μg/ml and the linear relationship was fine(r=0.999 4).The average recovery was 98.17%(n=9)

and RSD =1.69%.The entrapment efficiencies of capsaicin of three groups of samples were 83.17%

87.74%

and 85.26% respectively.Conclusion: This method can effectively eliminate the interference of the determination

which is suitable for the determination of encapsulation efficiency of capsaicin.

关键词

辣椒碱纳米乳包封率

Keywords

capsaicinnanoemulsionencapsulation efficiency

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