The resonance Rayleigh scattering spectra of the interaction between amikacin and pontamine sky blue and its application

HAN Wen-li; et al

doi:10.13406/j.cnki.cyxb.2011.02.002

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The resonance Rayleigh scattering spectra of the interaction between amikacin and pontamine sky blue and its application

更新时间：2024-01-17

- The resonance Rayleigh scattering spectra of the interaction between amikacin and pontamine sky blue and its application
- Journal of Chongqing Medical University Vol. 36, Issue 2, Pages: 185-188(2011)
- 作者机构：
  
  重庆医科大学药学院药物分析教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.02.002
  CLC： R927;TQ460.7
- Published：2011，
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[1]韩文莉,曲斐,陆巍,尚京川.滂胺天蓝与阿米卡星相互作用的共振瑞利散射光谱及其应用[J].重庆医科大学学报,2011,36(02):185-188.

HAN Wen-li, et al. The resonance Rayleigh scattering spectra of the interaction between amikacin and pontamine sky blue and its application. [J]. Journal of Chongqing Medical University 36(2):185-188(2011)
[1]韩文莉,曲斐,陆巍,尚京川.滂胺天蓝与阿米卡星相互作用的共振瑞利散射光谱及其应用[J].重庆医科大学学报,2011,36(02):185-188. DOI： 10.13406/j.cnki.cyxb.2011.02.002.

HAN Wen-li, et al. The resonance Rayleigh scattering spectra of the interaction between amikacin and pontamine sky blue and its application. [J]. Journal of Chongqing Medical University 36(2):185-188(2011) DOI： 10.13406/j.cnki.cyxb.2011.02.002.

摘要

目的:采用共振瑞利散射法（Resonance Rayleigh scattering

RRS）测定不同制剂中阿米卡星（Amikacin

AMK）的含量。方法:考察RRS增强的机理、反应条件对RRS强度的影响以及AMK浓度与RRS强度的关系。结果:在pH3.0的Britton-Robinson缓冲液中

滂胺天蓝（Pontamine sky blue

PSB）与AMK在静电引力及疏水性作用结合成组成比为2∶1的离子缔合物。AMK的浓度在0.01～1.7 mg/L范围内与RRS强度成正比

检出限（3σ）为3.0μg/L。结论:该法简便快速、结果准确可靠

可用于不同制剂中AMK的含量测定。

Abstract

Objective:To determine simply and rapidly amikacin(AMK) in different pharmaceutical formulations with resonance Rayleigh scattering(RRS) method.Methods:The mechanism of generating greatly enhanced RRS signals

the effects of the interacting conditions on the enhanced intensity of RRS

and the relationship between the enhanced RRS intensity and the concentration of AMK were investigated.Results:In a Britton-Robinson buffer solution(pH3.0)

AMK interacted with pontamine sky blue(PSB) to form an ion-association complex with the composition ratio of 2∶1 by virtue of electrostatic attraction and hydrophobic effect.It was found that the enhanced intensity of RRS was in good proportion to the concentration of AMK in the range of 0.01～1.7 mg/L with the detection limit(3σ) at 3.0 μg/L.Conclusion:The method is satisfactorily applied to the determination of AMK in different pharmaceutical formulations.

关键词

共振瑞利散射阿米卡星滂胺天蓝

Keywords

resonance Rayleigh scatteringamikacinpontamine sky blue

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Department of Neonatology, Children's Hospital of Chongqing Medical University; National Clinical Research Center For Child Health and Disorders; Ministry of Education Key Laboratory of Child Development and Disorders; Chongqing Key Laboratory of Pediatrics

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